The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis

Psychiatry and Clinical Neurosciences
Claude Gottesmann


This paper describes a hypothesis related to the neurochemical background of sleep-waking mental activity which, although associated with subcortical structures, is principally generated in the cerebral cortex. Acetylcholine, which mainly activates cortical neurons, is released at the maximal rate during waking and rapid eye movement (REM) sleep dreaming stage. Its importance in mental functioning is well-known. However, brainstem-generated monoamines, which mainly inhibit cortical neurons, are released during waking. Both kinds of influences contribute to the organized mentation of waking. During slow wave sleep, these two types of influence decrease in intensity but maintain a sufficiently high level to allow mental activity involving fairly abstract pseudo-thoughts, a mode of activity modelled on the diurnal pattern of which it is a poor reply. During REM sleep, the monoaminergic neurons become silent except for the dopaminergic ones. This results in a large disinhibition and the maintained dopamine influence may be involved in the familiar psychotic-like mental activity of dreaming. Indeed, in this original activation-disinhibition state, the increase of dopamine influence at the prefrontal cortex level could explain the al...Continue Reading


Jun 1, 1979·Journal of Affective Disorders·P A CobleR J McPartland
Feb 18, 1977·Brain Research·H L Haas, P Wolf
Aug 1, 1976·European Journal of Pharmacology·B S Sastry, J W Phillis
Jan 23, 1976·Brain Research·D J McGinty, R M Harper
Dec 1, 1992·Sleep·C CavalleroA Zito
Jan 1, 1991·Neuroscience·R R Llinás, D Paré
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U RibaryR Llinás
Nov 1, 1991·Physiology & Behavior·L GlinC Gottesmann
Jan 1, 1991·Physiological Reviews·J C SchwartzM Ruat
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P L MadsenG Wildschiødtz
Jul 1, 1990·Archives of General Psychiatry·N C AndreasenS Arndt
Apr 1, 1987·Electroencephalography and Clinical Neurophysiology·S MiyauchiS Torii
Feb 1, 1989·Journal of Abnormal Psychology·M F LenzenwegerE Wethington
Oct 13, 1987·Brain Research·M F DaviesS J Peroutka
Jun 1, 1987·Cellular and Molecular Neurobiology·C W CallawayJ A Hobson
May 1, 1966·Electroencephalography and Clinical Neurophysiology·M DemetrescuG Iosif
Jan 1, 1971·Brain : a Journal of Neurology·J D SpillaneC D Marsden
Mar 1, 1969·Psychophysiology·J D Larson, D Foulkes
Feb 6, 1970·Science·R W McCarley, J A Hobson
Jul 28, 1972·Nature·J L ValatxM Jouvet
Apr 1, 1974·Perceptual and Motor Skills·R L Tracy, L N Tracy
Dec 24, 1971·Brain Research·R C FredericksonJ W Phillis
Jan 1, 1971·Brain : a Journal of Neurology·K C HayesT P Faherty
Sep 1, 1980·Brain Research Bulletin·G GandolfoC Gottesmann
Sep 1, 1982·Archives of General Psychiatry·A V MackayS H Synder
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen, S Olsen
Jul 1, 1995·Behavioural Brain Research·M Bosinelli

❮ Previous
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Jul 29, 2005·The International Journal of Neuroscience·D L RoweL M Williams
Dec 6, 2006·Expert Review of Neurotherapeutics·Donald L Rowe, Daniel F Hermens
Sep 9, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·V S Rotenberg
Mar 16, 2012·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Toshiyuki Kobayashi, Mina Yamauchi
Apr 6, 2016·Frontiers in Neural Circuits·Tiago L RibeiroMauro Copelli
Jun 24, 2004·Brain Research. Brain Research Reviews·Claude Gottesmann
Nov 23, 2006·Neuropsychologia·Todd A GirardJ Allan Cheyne
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