The NeuroGrid stroke exemplar clinical trial protocol.

International Journal of Stroke : Official Journal of the International Stroke Society
J M WardlawAndrew Farrall

Abstract

Trials of new treatments for neurological disorders like stroke require imaging as part of the patient assessment, but need to be large enough to obtain reliable results if treatment effects are likely to be modest. However, multicentre trials use many different scanners in different hospitals and present complex problems for image data collection, interpretation and analysis and long-term secure archiving. NeuroGrid aims to develop and test grid technologies for collecting, analysing and interpreting, and secure archiving of neuroimaging data for large multicentre trials in common neurological and psychiatric disorders. A 3-year multicentre consortium of clinicians, neuroimaging centres and e-scientists are designing a Grid storage network, mechanisms for uploading, curating and retrieving image and metadata, combining image data from different scanners and an analysis tool box. Three clinical exemplars--stroke, dementia and psychosis--provide the data and 'real-world' clinical trial applications, and a set of specific and typical problems encountered with image data in multicentre trials for NeuroGrid to address. The stroke exemplar is using image data from two multicentre stroke trials: Third International Stroke Trial and E...Continue Reading

References

Jun 1, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B SilverV Hachinski
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·William WhiteleyUNKNOWN IST-3 Collaborative Group

❮ Previous
Next ❯

Citations

Jun 10, 2009·Current Opinion in Neurology·John Darrell Van Horn, Arthur W Toga
Nov 26, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·P M W BathA R Green
Mar 5, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Philip M W BathUNKNOWN ENOS Trialists
Feb 3, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Philip M W BathUNKNOWN TARDIS Trialists
Nov 5, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Philip Mw BathNikola Sprigg
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Nov 27, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Philip M BathNikola Sprigg
Jan 19, 2019·The Cochrane Database of Systematic Reviews·Malene Plejdrup HansenChris B Del Mar

❮ Previous
Next ❯

Software Mentioned

NeuroGrid
GESIRS
SMPTE
ACCESS
ENOS
SIRS
DICOM

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Related Papers

International Journal of Stroke : Official Journal of the International Stroke Society
Philip M W Bath, Laura J Gray
European Journal of Nuclear Medicine and Molecular Imaging
Stefan J TeipelHarald Hampel
Journal of Physiology, Paris
Andreas Otte, Ulrike Halsband
Nature Reviews. Neurology
Giovanni B FrisoniPaul M Thompson
© 2022 Meta ULC. All rights reserved