The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation

Biological Chemistry Hoppe-Seyler
M RehbeinD Richter

Abstract

Complete cDNA sequences for the vasopressin and oxytocin precursor polyproteins have been determined for the rat, calf, human and pig (vasopressin only), indicating the essential conservation of the precursor structures throughout mammals. DNA probes specific for vasopressin or oxytocin mRNAs have been used to identify both classic (hypothalamic) and novel (thymus, corpus luteum, phaeochromocytoma) sites of hormone expression. Semiquantitative DNA/RNA hybridization suggests that in rats expression of the vasopressin and oxytocin genes is positively effected by osmotic stress, negatively by a systemically applied excess of vasopressin; in the latter experiment a reduction in the hypothalamic levels of vasopressin and oxytocin mRNAs in normal and Brattleboro rats have been observed. This suggests a feedback regulation by the hormone as a possible element in controlling the transcription of the vasopressin gene.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1979·Annual Review of Biochemistry·M Heidelberger
Nov 1, 1983·International Journal of Peptide and Protein Research·N RawlingsB Wittmann-Liebold

❮ Previous
Next ❯

Citations

Apr 29, 1993·Regulatory Peptides·H D Nicholson, B T Pickering
Feb 1, 1992·Molecular and Cellular Endocrinology·M D GuillouC Clamagirand
Apr 1, 1988·Domestic Animal Endocrinology·T H Wise
Sep 18, 1998·Brain Research·O LabudovaG Lubec
Mar 23, 2000·Theriogenology·E D WatsonJ Goode
Apr 16, 1998·Regulatory Peptides·C H Hoyle
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J HeierhorstD Richter
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K NishimoriM M Matzuk
Jun 1, 1991·Clinical Endocrinology·J S Jenkins, S S Nussey
Jan 1, 1992·The European Journal of Neuroscience·Evita Mohr, Dietmar Richter
Jul 1, 1990·The Journal of Clinical Investigation·J K KimR W Schrier
Oct 1, 1990·The Journal of Clinical Investigation·A G RobinsonT G Sherman
Jan 1, 1993·The Journal of Clinical Investigation·R ChibbarB F Mitchell
Aug 1, 1992·Journal of Neuroendocrinology·D HamannR Ivell
Oct 1, 1992·Journal of Neuroendocrinology·W S Young
Sep 15, 1989·The Journal of Comparative Neurology·A R CafféF W Van Leeuwen
Nov 1, 1990·Kidney International·J K KimR W Schrier
Jan 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H J PyoR W Schrier
Feb 14, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Margareta SteinwallMats Akerlund
Jan 1, 1989·Annals of the New York Academy of Sciences·B T PickeringL Yavachev
Oct 31, 1988·Biochemical and Biophysical Research Communications·U Nörenberg, D Richter
Jan 24, 2002·The Journal of Pharmacy and Pharmacology·M MoritaY Notsu
Jan 16, 1999·Molecular Genetics and Metabolism·R W SchrierM Knotek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.