PMID: 11607923Oct 19, 2001Paper

The neuroimmunology of stress and depression

Seminars in Clinical Neuropsychiatry
C L Raison, A H Miller

Abstract

This article reviews evidence that shows a bidirectional relationship between the brain and the immune system. As a result of this relationship, mental factors such as stress and depression have been shown to affect immune system functioning, with both immunosuppression and immune activation being reported. Stress and depression also have been associated with worse outcomes in immune-related disorders including cancer and infectious diseases suggesting that stress/depression effects on the immune system are clinically relevant to disease expression. Conversely, several lines of evidence suggest that immune system activation such as during infectious diseases, cancer, and autoimmune disorders is associated with the development of behavioral symptoms similar to those seen in the context of chronic stress or major depression. These findings implicate a role for the immune system in the cause of behavioral disorders in a wide range of medical illnesses. Finally, a paradigm is proposed in which abnormal functioning of either the hypothalamic-pituitary-adrenal (HPA) axis or the inflammatory response system disrupts feedback regulation of both neuroendocrine and immune systems contributing to the development of neuropsychiatric and im...Continue Reading

Citations

Nov 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohong WangAndrew H Miller
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Harriet Scheft, Dominique C Fontenette
Jul 27, 2007·Disability and Rehabilitation·Brick JohnstoneRichard E Oliver
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Oct 16, 2010·Psychosomatic Medicine·Tami BentonDwight L Evans
Dec 6, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Saeed KianbakhtAli Ghazavi
Mar 15, 2003·The Journal of International Medical Research·H JozukaO Nishikaze
Feb 9, 2005·CNS Drugs·Charles L RaisonAndrew H Miller
Jul 15, 2005·Current Opinion in Critical Care·Craig Weinert
Apr 29, 2010·Nutritional Neuroscience·Francisco J Vaz-LealM Angustias Garcia-Herráiz
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janine Giese-DavisDavid Spiegel
Oct 30, 2008·Journal of Immunotoxicology·Robert V House, Kenneth L Hastings
Jan 9, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·UNKNOWN Drafting Committee for Hepatitis Management Guidelines and the Japan Society of Hepatology
Dec 25, 2007·Pharmacotherapy·Heather M Draper
Nov 18, 2010·Circulation. Heart Failure·Sitaramesh Emani, Philip F Binkley
Jan 22, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·
Nov 21, 2007·JAAPA : Official Journal of the American Academy of Physician Assistants·Leslie Freels Lloyd, Laurie R Dunn
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Nov 13, 2009·Annals of the New York Academy of Sciences·Owen M WolkowitzVictor I Reus
Apr 9, 2010·Depression and Anxiety·Owen M WolkowitzSynthia H Mellon
Oct 3, 2006·Psychosomatic Medicine·Janine Giese-DavisDavid Spiegel
May 1, 2021·International Journal of Molecular Sciences·Eleonora FiciaràCaterina Guiot
Dec 6, 2003·Psychiatry Research·Gilberto GerraClaudio Franceschi
Aug 1, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Erwin L RoggenGeert R Verheyen
Mar 28, 2017·ACS Chemical Neuroscience·Matthew J RobsonRandy D Blakely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Jonathan P Godbout, Ronald Glaser
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
P M M Moraes-VieiraN O S Câmara
© 2021 Meta ULC. All rights reserved