PMID: 591996Dec 1, 1977

The neurological basis of motor asymmetry following unilateral 6-hydroxydopamine brain lesions in the rat: the effect of motor decortication

Journal of the Neurological Sciences
A R CrossmanP Slater

Abstract

The role of the motor cortex in the mediation of asymmetric movement after unilateral 6-hydroxydopamine (6-OHDA) brain lesions has been examined in the rat. The effect of unilateral and bilateral sensorimotor decortication upon spontaneous and drug (apomorphine and amphetamine)-induced motor asymmetry has been studied following unilateral injection of 6-OHDA into the lateral hypothalamus. Both bilateral decortication and unilateral decortication on the side of the 6-OHDA lesion caused a transient reversal of the spontaneous motor asymmetry normally seen in 6-OHDA lesioned animals. Neither unilateral nor bilateral sensorimotor decortication abolished drug-induced turning behaviour. It is postulated that subcortical basal ganglia efferent pathways may be involved in the mediation of motor asymmetry after unilateral 6-OHDA lesions of the nigrostriatal dopaminergic projection.

References

May 1, 1975·The American Journal of Anatomy·S P Hicks, C J D'Amato
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jan 1, 1966·Brain Research·W J Nauta, W R Mehler
Dec 1, 1952·The Journal of Nervous and Mental Disease·A E WALKER
Feb 1, 1956·The Journal of Comparative Neurology·F WALBERG
Dec 1, 1945·Annals of Surgery·P C Bucy

Citations

Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Jan 1, 1983·Journal of Neural Transmission·P N LeighC D Marsden
Jan 1, 1980·Progress in Neurobiology·A Dray
Jan 1, 1980·Neuroscience·C J Pycock
Jul 1, 1982·Brain Research Bulletin·G W Arbuthnott, A K Wright
Jan 28, 1982·Brain Research·B ScattonG Bartholini
Dec 1, 1982·Archives internationales de physiologie et de biochimie·G CrescimannoG Amato

Related Concepts

Mydrial
Metazoa
Apokinon
Claustral Structure
Lenticulostriate Disorders
Functional Cerebral Localization
Cerebral Decortication
Paleostriatum
Hydroxydopamine
Motor Cortex

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.