The neurologist's approach to cerebral infarct and transient ischaemic attack in patients receiving anticoagulant treatment for non-valvular atrial fibrillation: ANITA-FA study

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G Zapata-Wainbergresearchers in the ANITA-FA study

Abstract

The aim of this study was to describe the clinical and epidemiological characteristics of acute ischaemic stroke (AIS) in patients with atrial fibrillation (AF) previously treated with oral anticoagulants (OACs) according to the type of OAC prescribed. Also, to analyze the outcomes of the patients and the therapeutic approach adopted by the neurologist in the acute phase and for secondary prevention. We performed a multicenter, observational study based on prospective registries. We included patients with AF treated with OACs admitted for AIS over a 1-year period. Detailed clinical data and functional outcome at 3 months (modified Rankin Scale score) were collected. Patients were divided into two groups according to their pre-AIS anticoagulant therapy: vitamin K antagonists (AIS-VKA) and direct-acting OACs (AIS-DOAC). We recruited 1240 patients (80.4% AIS-VKA and 19.6% AIS-DOAC). In the AIS-DOAC group, transient ischaemic attack was more frequent (18.1% vs. 10.8%; P = 0.001), symptomatic hemorrhagic transformation was less frequent (1.6% vs. 4.6%; P = 0.035) and hospital stay was shorter (median 6 vs. 7 days; P = 0.03). Intravenous thrombolysis was more commonly used in AIS-VKA (9.2% vs. 1.6%; P < 0.001). There were no differen...Continue Reading

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Citations

Jan 12, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G VilanilamA Nandakumar
Jan 12, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G Zapata-WainbergJ Vivancos
Apr 9, 2020·Current Pharmaceutical Design·Bunny SaberwalNikolaos Papageorgiou
Oct 31, 2020·Cellular and Molecular Neurobiology·Chengli LiuWei Wang
Nov 17, 2020·Frontiers in Neurology·Raquel Gutiérrez-ZúñigaExuperio Díez-Tejedor

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