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The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria

The Journal of Biological Chemistry

May 22, 2009

Alexander V PanovBenjamin Rix Brooks

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Abstract

The finding that upon neuronal activation glutamate is transported postsynaptically from synaptic clefts and increased lactate availability for neurons suggest that brain mitochondria (BM) utilize a mixture of substrates, namely pyruvate, glutamate, and the tricarboxylic acid cycle meta...read more

Mentioned in this Paper

Synapses
Respiration
Pyruvate Measurement
Oxidation-Reduction
Substrate Specificity
Lactates
Lactic Acid Measurement
Electron Transport
Succinates
Glutamate
40
Paper Details
References
  • References42
  • Citations24
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  • References42
  • Citations24
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The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria

The Journal of Biological Chemistry

May 22, 2009

Alexander V PanovBenjamin Rix Brooks

PMID: 19304986

DOI: 10.1074/jbc.m900985200

Abstract

The finding that upon neuronal activation glutamate is transported postsynaptically from synaptic clefts and increased lactate availability for neurons suggest that brain mitochondria (BM) utilize a mixture of substrates, namely pyruvate, glutamate, and the tricarboxylic acid cycle meta...read more

Mentioned in this Paper

Synapses
Respiration
Pyruvate Measurement
Oxidation-Reduction
Substrate Specificity
40

Related Papers

Paper Details
References
  • References42
  • Citations24
12345
  • References42
  • Citations24
123

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