The neuronal and actin commitment: Why do neurons need rings?

Cytoskeleton
Sérgio Carvalho Leite, Mónica Mendes Sousa

Abstract

The role of the actin cytoskeleton in neurons has been extensively studied in actin-enriched compartments such as the growth cone and dendritic spines. The recent discovery of actin rings in the axon shaft and in dendrites, together with the identification of axon actin trails, has advanced our understanding on actin organization and dynamics in neurons. However, specifically in the case of actin rings, the mechanisms regulating their nucleation and assembly, and the functions that they may exert in axons and dendrites remain largely unexplored. Here we discuss the possible structural, mechanistic and functional properties of the subcortical neuronal cytoskeleton putting the current knowledge in perspective with the information available on actin rings formed in other biological contexts, and with the organization of actin-spectrin lattices in other cell types. The detailed analysis of these novel neuronal actin ring structures, together with the elucidation of the function of actin-binding proteins in neuron biology, has a large potential to uncover new mechanisms of neuronal function under normal conditions that may have impact in our understanding of axon degeneration and regeneration. © 2016 Wiley Periodicals, Inc.

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Citations

Apr 14, 2016·Cell Reports·Sérgio Carvalho LeiteMónica Mendes Sousa
Nov 4, 2017·Nature Reviews. Neuroscience·Christophe LeterrierSubhojit Roy
Sep 17, 2019·Cytoskeleton·Maral Adeli KoudehiDimitrios Vavylonis
Sep 21, 2018·Frontiers in Molecular Neuroscience·Ana Rita CostaMónica Mendes Sousa
Dec 22, 2019·Nature Communications·Stéphane VassilopoulosChristophe Leterrier
Dec 2, 2020·Neurobiology of Disease·Carolyn E Keating, D Kacy Cullen
Apr 27, 2021·Computational and Structural Biotechnology Journal·Md Ishak KhanAshfaq Adnan
Jun 20, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Xiaorong PanTong Wang
Aug 28, 2021·International Journal of Molecular Sciences·Béatrice BenoitChristian Poüs

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