The neuropeptide galanin is a novel inhibitor of human hair growth

The British Journal of Dermatology
Barbara S HolubR Paus

Abstract

Galanin is a trophic factor of the central and peripheral nervous system that shows widespread distribution in human skin. However, the exact localization and the role of galanin in the hair follicle (HF) remain to be clarified. To characterize galanin expression in human scalp HFs and to examine the effects of galanin on normal human scalp HF growth in organ culture. Immunohistochemistry was performed on cryosections of human female scalp skin. Anagen HFs were microdissected and cultured up to 9 days and treated with 100 nmol L(-1) galanin. Staining for Ki-67, TUNEL and Masson-Fontana were used to analyse proliferation, apoptosis and hair cycle staging of the HFs. Functional effects of galanin were tested in serum-free HF organ culture. Galanin-like immunoreactivity was detected in the outer root sheath (ORS) and inner root sheath. Additionally, galanin mRNA was detected in ORS keratinocytes and all HF samples tested. Galanin receptor transcripts (GalR2, GalR3) were also detected in selected samples. Galanin reduced proliferation of hair matrix keratinocytes in situ compared with vehicle-treated controls, shortened the hair growth phase (anagen) in vitro and reduced hair shaft elongation. This was accompanied by the premature ...Continue Reading

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Citations

Feb 19, 2013·PloS One·Naoko MorisakiShigeru Moriwaki
Jul 30, 2014·Trends in Molecular Medicine·Ralf PausBogi Andersen
May 14, 2017·Molecular Ecology·Mafalda S FerreiraJosé Melo-Ferreira
Apr 26, 2018·Experimental Dermatology·Michael P Philpott
Jul 19, 2013·International Review of Psychiatry·Deirdre Johnston
Aug 1, 2020·International Journal of Molecular Sciences·Monika GrymowiczBlazej Meczekalski

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