The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis

Circulation Research
Ilze BotErik A L Biessen

Abstract

Although we and others have recently shown that mast cells play an important role in plaque progression and destabilization, the nature of the actual trigger for (peri)vascular mast cell activation during atherosclerosis is still unresolved. In this study, we confirm that perivascular mast cell content correlates with the number of nerve fibers in the adventitia of human coronary atherosclerotic plaque specimen. Because peripheral C-type nerve fibers secrete, among others, substance P, a potent mast cell activator, we set out to study effects of adventitial administration of this neuropeptide on mast cell dependent destabilization of carotid artery plaques in apolipoprotein E-deficient (apoE(-/-)) mice. Substance P treatment significantly enhanced the number and activation status of adventitial mast cells compared to controls and promoted intraplaque hemorrhages. These phenomena could be prevented by coadministration of the neurokinin-1 receptor antagonist spantide I and did not occur in mast cell deficient apoE(-/-) mice, establishing the critical involvement of mast cells in substance P-elicited plaque destabilization. Our data suggest that neurotransmitters such as substance P are capable of promoting mast cell dependent pla...Continue Reading

References

Sep 1, 1988·British Journal of Pharmacology·M A LowmanM K Church
Oct 1, 1984·British Journal of Pharmacology·K FolkersS Leander
Oct 1, 1996·The Journal of Pathology·A NaukkarinenM Horsmanheimo
Jan 14, 1999·The New England Journal of Medicine·R Ross
Dec 14, 2002·Brain, Behavior, and Immunity·Paul H Black
Mar 20, 2003·Journal of the American College of Cardiology·Prediman K Shah
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Jul 31, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Helena LappalainenPetri T Kovanen
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Jan 13, 2006·British Journal of Pharmacology·Susan D Brain, Helen M Cox
Jun 5, 2007·Nature Medicine·Jiusong SunGuo-Ping Shi

❮ Previous
Next ❯

Citations

Dec 1, 2010·Journal of Cardiovascular Translational Research·Peter J PsaltisRobert D Simari
Oct 17, 2012·Cardiovascular Research·Margreet R de VriesPaul H A Quax
Jan 14, 2012·Endocrine Reviews·Jia-Ming Xu, Guo-Ping Shi
May 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Preet AnandNirmal Singh
Jul 12, 2011·Trends in Pharmacological Sciences·Theoharis C TheoharidesDimitrios Kalogeromitros
Nov 8, 2014·Hämostaseologie·A WezelI Bot
Aug 26, 2011·Thrombosis and Haemostasis·I Bot, E A L Biessen
Aug 12, 2015·Nature Reviews. Cardiology·Guo-Ping ShiPetri T Kovanen
Jan 17, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michail AlevizosTheoharis C Theoharides
May 12, 2015·European Journal of Pharmacology·Eva KritikouIlze Bot
Jan 22, 2013·Pharmacology & Therapeutics·Simon KennedyPasquale Maffia
Jul 8, 2011·Medical Hypotheses·Yan Bo Li, Cong Xin Huang
Nov 30, 2013·International Journal of Cardiology·Heather M Dehlin, Scott P Levick
May 2, 2014·Frontiers in Immunology·George Nikov ChaldakovLuigi Aloe
Jul 1, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U RaapM Schmelz
Jan 6, 2017·Nature Reviews. Cardiology·Ehsan Azimi, Ethan A Lerner
Jan 6, 2017·Nature Reviews. Cardiology·Guo-Ping ShiPetri T Kovanen
Aug 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Ilze BotPetri T Kovanen
Sep 11, 2019·International Journal of Molecular Sciences·Gilda VarricchiStephen J Galli
Jan 1, 2013·Brain Sciences·Renée J Turner, Robert Vink
Oct 26, 2018·Circulation·Giampaolo NiccoliFilippo Crea
Mar 30, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bindu ChandrasekharanShanthi Srinivasan
Jul 25, 2019·Frontiers in Cellular Neuroscience·Gilda VarricchiGiuseppe Spadaro
Nov 26, 2010·Expert Review of Cardiovascular Therapy·Jennifer E ColeClaudia Monaco
Oct 11, 2020·Current Cardiology Reports·Samit M ShahRobert Soufer
Jul 2, 2020·Trends in Immunology·Gilda VarricchiPetri T Kovanen
Oct 9, 2018·Trends in Neurosciences·Paul Forsythe

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.