The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.

Cell
Moriel ZelikowskyDavid J Anderson

Abstract

Chronic social isolation causes severe psychological effects in humans, but their neural bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) caused multiple behavioral changes in mice and induced brain-wide upregulation of the neuropeptide tachykinin 2 (Tac2)/neurokinin B (NkB). Systemic administration of an Nk3R antagonist prevented virtually all of the behavioral effects of chronic SIS. Conversely, enhancing NkB expression and release phenocopied SIS in group-housed mice, promoting aggression and converting stimulus-locked defensive behaviors to persistent responses. Multiplexed analysis of Tac2/NkB function in multiple brain areas revealed dissociable, region-specific requirements for both the peptide and its receptor in different SIS-induced behavioral changes. Thus, Tac2 coordinates a pleiotropic brain state caused by SIS via a distributed mode of action. These data reveal the profound effects of prolonged social isolation on brain chemistry and function and suggest potential new therapeutic applications for Nk3R antagonists.

Citations

Mar 16, 2019·Annals of the New York Academy of Sciences·Gillian A Matthews, Kay M Tye
Mar 16, 2019·Social Cognitive and Affective Neuroscience·Chunliang FengPengfei Xu
Apr 6, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Moriel ZelikowskyDavid J Anderson
Dec 14, 2019·The European Journal of Neuroscience·Masumi AkibaTakako Morimoto
Oct 23, 2019·Annual Review of Physiology·Christi M GendronScott D Pletcher
May 23, 2020·Science·Noah Snyder-MacklerJenny Tung
Aug 29, 2019·Nature Neuroscience·Daniel A GehrlachNadine Gogolla
Sep 18, 2020·Nature·Ann KennedyDavid J Anderson
Aug 22, 2018·Journal of Experimental Neuroscience·Lei Li, Liping Wang
Jan 11, 2019·Frontiers in Neural Circuits·Tomas HökfeltSven Ove Ögren
Jun 28, 2019·Frontiers in Behavioral Neuroscience·Graziano Pinna
Feb 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Naresh K HanchateLinda B Buck
Oct 5, 2018·Cell and Tissue Research·W Zieglgänsberger
Sep 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Meghan E Flanigan, Scott J Russo
Jan 11, 2019·Nature Protocols·Rosemary C ChallisViviana Gradinaru
Jul 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Julia M GeorgeDavid F Clayton
Jun 12, 2020·Frontiers in Behavioral Neuroscience·Arish Mudra Rakshasa, Michelle T Tong
Jul 1, 2018·Nature·Noga Zilkha, Tali Kimchi
Nov 14, 2019·International Journal of Molecular Sciences·Iulia Zoicas, Johannes Kornhuber
Oct 22, 2020·Metallomics : Integrated Biometal Science·Yaliang HuangJianxiu Wang
Nov 21, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mark Dombrovski, Barry Condron
Jul 25, 2019·SSM - Population Health·Christopher G Hudson, Nathan J Doogan
Nov 17, 2020·Frontiers in Systems Neuroscience·Jay Love, Moriel Zelikowsky
Nov 17, 2020·Frontiers in Genetics·Rodrigo G Arzate-MejíaIsabelle M Mansuy
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Minsuk HyunBernardo L Sabatini
Dec 4, 2020·Nature·Lukas AnneserErin M Schuman
Feb 28, 2021·Science Advances·Andrew T LuskinMichael R Bruchas
Feb 27, 2021·Frontiers in Behavioral Neuroscience·William J Giardino, Matthew B Pomrenze
Apr 20, 2021·Biological Psychiatry·A Shaam Al AbedNathalie Dehorter
May 5, 2021·Nature Communications·A FloridoR Andero
May 4, 2021·Current Opinion in Neurobiology·Tara Raam, Weizhe Hong
Jun 7, 2021·Behavioural Brain Research·Maria M Ortiz-JuzaJose Rodriguez-Romaguera
Nov 14, 2020·Current Biology : CB·Assa BentzurGalit Shohat-Ophir
Aug 20, 2021·Life Science Alliance·Cristin D DavidsonWilliam J Pavan

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