The neuroplastic effect of olfactory training to the recovery of olfactory system in mouse model

International Forum of Allergy & Rhinology
Boo-Young KimSoo Whan Kim

Abstract

Several studies have reported the benefits of olfactory training (OT) in the olfactory nervous system of mouse models. Therefore, in this study we performed next-generation sequencing to evaluate the effects of OT on mRNA sequencing in the olfactory area. Mice in each group were administered 300 mg of 3-methylindole per kilogram of mouse weight. The olfactory function was evaluated by a food-finding test once a week. The olfactory neuroepithelium was harvested for histologic examination and protein analysis. Subsequently, data analysis, gene ontology and pathway analysis, quantitative real-time polymerase chain reaction of mRNA, and Western blot analysis were conducted. Mice were divided into 4 groups according to treatment. Control, anosmia, training, and steroid group mice resumed food finding. Olfactory Maker Protein, olfr1507, ADCY3, and GNAL mRNA expression was higher in the olfactory neuroepithelium of OT than anosmia group mice. In total, 26,364 mRNAs were analyzed. Comparison of the results of OT vs anosmia revealed that ADCY8,10, GFAP, NGF, NGFR, GFAP, and BDNF mRNAs were upregulated in the gene ontology. OT improved olfactory function, as indicated by the food-finding test. OT improved the olfactory recovery time to s...Continue Reading

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Citations

Jul 18, 2019·International Forum of Allergy & Rhinology·David W Kennedy
Nov 5, 2019·American Journal of Rhinology & Allergy·Boo-Young KimByungGuk Kim
Aug 11, 2020·International Forum of Allergy & Rhinology·Justin H Turner
Jun 23, 2020·American Journal of Rhinology & Allergy·Boo-Young KimEuiJin Kim
Jul 11, 2020·Current Allergy and Asthma Reports·Concepció MarinJoaquim Mullol
Apr 14, 2021·Journal of the Neurological Sciences·Stéphane MathisGuilhem Solé
Jul 9, 2021·American Journal of Rhinology & Allergy·Boo-Young KimJung H Bae

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Methods Mentioned

BETA
dissecting
PCR
electrophoresis

Software Mentioned

Bedtools
Bioconductor
Bowtie2
EdgeR
PASW Statistics
R R Development
SPSS
QuantSeq

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