PMID: 8581565Sep 1, 1995Paper

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration
S G SydserffA R Green

Abstract

The ability of chlormethiazole to protect against ischaemic cell damage in a rat model of permanent focal ischaemia has been examined. Chlormethiazole (1 mmol/kg) was administered intraperitoneally either 1 or 3 h after occlusion of the middle cerebral artery with an intraluminal filament. Twenty four hours after the start of occlusion there was histological evidence for ischaemic damage in both cortex and striatum. The volume of ischaemic damage in control (saline injected) animals was 310 +/- 25 mm3 (mean +/- SEM; n = 6). Chlormethiazole administered 1 h after occlusion reduced this damage by 58% (128 +/- 40 mm3; n = 6; P < 0.01), protection being observed in both brain regions. The drug was ineffective when given 3 h after occlusion (304 +/- 25 mm3; n = 5). Chlormethiazole had no effect on body temperature, mean arterial blood pressure, blood pH, pO2 or pCO2, but did induce mild bradycardia. Chlormethiazole therefore appears to be an effective neuroprotective agent in this model of permanent ischaemia, complementing previous data on the efficacy of this drug in other focal and global models of cerebral ischaemia.

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Feb 1, 1989·Stroke; a Journal of Cerebral Circulation·L L SternauR Ratcheson
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D I Graham
Apr 1, 1995·Trends in Pharmacological Sciences·A J HunterA J Cross

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Citations

Oct 9, 2002·Current Medical Research and Opinion·Anand Vaishnav, Helmi L Lutsep
Mar 1, 2008·Neuropharmacology·Myron D Ginsberg
Aug 5, 2003·British Journal of Clinical Pharmacology·Per-Henrik ZingmarkE Niclas Jonsson
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·P D LydenS Martin-Munley
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·N G WahlgrenUNKNOWN CLASS study group
Dec 17, 2014·Clinical Neurology and Neurosurgery·Stephen GrupkeJustin F Fraser
Sep 22, 2016·Scientific Reports·Andrew J SamsonChristopher N Connolly
Dec 11, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F DajasA Morquio
Apr 12, 2001·Journal of Neurochemistry·R D Schwartz-Bloom, R Sah
Jul 25, 2018·CNS Neuroscience & Therapeutics·Xiao-Mei JiangXiao-Liang Wang
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·P LydenR L Macdonald
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·P LydenUNKNOWN CLASS-I/H/T Investigators
Jan 13, 2004·Neurotoxicity Research·Federico DajasHoracio Heizen
Oct 9, 2002·Clinical and Experimental Pharmacology & Physiology·A Richard Green
Dec 14, 2004·CNS Drug Reviews·M J Wilby, P J Hutchinson
Aug 8, 2021·International Journal of Molecular Sciences·Natalia CichonMichal Bijak

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