The Neuroprotective Effect of Doxycycline on Neurodegenerative Diseases

Neurotoxicity Research
Flávia Viana Santa-CecíliaRita Raisman-Vozari

Abstract

Neurodegenerative diseases (NDs) are a group of chronic, progressive disorders characterized by the gradual loss of neurons that affect specific regions of the brain, which leads to deficits in specific functions (e.g., memory, movement, cognition). The mechanism that drives chronic progression of NDs remains elusive. Among the proposed underlying pathophysiological mechanisms, aggregation and accumulation of misfolded proteins and neuroinflammation have been credited to contribute to extensive neural loss. Therapeutic agents that confer neuroprotection by downregulating these shared characteristics could therefore have beneficial effects on a wide range of NDs. In this regard, a commonly used antibiotic, doxycycline (Doxy), has been shown to reduce the progression and severity of disease in different experimental models of neurodegeneration by counteracting these common features. This review will focus on the effects reported for Doxy regarding its neuroprotective properties, the "off-target" effects, thereby supporting its evaluation as a new therapeutic approach for diseases associated with a neurodegeneration.

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Citations

Jan 15, 2020·Current Pharmaceutical Design·Octavio Binvignat, Jordi Olloquequi
Aug 28, 2019·International Journal of Molecular Sciences·Parisa Gazerani
Nov 11, 2019·Acta Neuropathologica Communications·Alexander J MoszczynskiKathryn Volkening
Jul 25, 2019·Frontiers in Pharmacology·Claudia Balducci, Gianluigi Forloni
Jan 12, 2021·Neurobiology of Disease·Antonio Dominguez-MeijideTiago Fleming Outeiro
Jan 20, 2021·Fundamental & Clinical Pharmacology·Khashayar AfshariAmir Hossein Abdolghaffari
Mar 23, 2021·British Journal of Pharmacology·Mariza BortolanzaElaine Del-Bel
Jul 16, 2021·Therapeutic Advances in Chronic Disease·Noha O MansourRehab H Werida
Jan 5, 2022·Journal of Neural Transmission·Iva MarkulinMelita Salković-Petrisic

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