The Neuroprotective Effect of Mesna on Cisplatin-Induced Neurotoxicity: Behavioral, Electrophysiological, and Molecular Studies.

Neurotoxicity Research
Hakimeh SaadatiAli Niapour

Abstract

Peripheral neuropathy and cognitive impairments following cisplatin administration may interfere with the clinical usage of the drug. Mesna is a chemoprotective agent with anti-inflammatory and anti-oxidant effects. Our study aimed to investigate the protective effects of mesna against cisplatin-induced neurotoxicity. Neurotoxicity was induced by the administration of 2.5 mg/kg cisplatin twice a week for four consecutive weeks in male Wistar rats. The neuroprotective effect of mesna (150 mg/kg/day) was evaluated through behavioral, electrophysiological, and molecular studies. Cisplatin treatment caused passive avoidance memory impairment, increased anxiety-like behaviors, altered thermal sensitivity, and decreased muscle strength in a grip strength test. Our electrophysiological studies indicated that administration of cisplatin induced peripheral sensory neuropathy and decreased the amplitudes of the compound action potential of sensory nerves. Cisplatin administration increased MDA and 4-HNE levels and decreased anti-oxidant (SOD and GPx) enzymes. Proinflammatory cytokines (IL-1β and TNF-α) and metalloproteinase-2 and 9 (MMP-2/9) were increased by cisplatin treatment. Morphological alterations were observed in the dorsal root...Continue Reading

References

Nov 1, 1994·Journal of the Neurological Sciences·R Gerritsen van der HoopF G Jennekens
Oct 3, 1999·Experimental Neurology·G TrediciG Cavaletti
Nov 25, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Milena Morais VieiraRonaldo Albuquerque Ribeiro
Aug 11, 2004·Burns : Journal of the International Society for Burn Injuries·Göksel SenerBerrak Yeğen
Feb 17, 2005·European Journal of Pharmacology·Azza El-MedanyGamila El-Medany
May 12, 2005·Cancer Chemotherapy and Pharmacology·S M F JamiesonM J McKeage
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaochun Jin, Robert W Gereau
Apr 9, 2008·American Journal of Obstetrics and Gynecology·John YehJennifer Peresie
Nov 27, 2008·Cancer Chemotherapy and Pharmacology·Chrissa Sioka, Athanassios P Kyritsis
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander M BinshtokTarek A Samad
Jun 16, 2009·Trends in Pharmacological Sciences·Ru-Rong JiEng H Lo
Feb 2, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Habibullah DolgunHakan Tuna
Aug 20, 2010·Cardiovascular Therapeutics·Ahmed A Elmarakby, Jennifer C Sullivan
Sep 1, 2010·Asian Journal of Sports Medicine·Hakimeh SaadatiMohammad Mashhadi
Sep 1, 2012·Neurotoxicology·Mohammad ShabaniFatemeh Abareghi
Oct 12, 2012·Acta neurochirurgica·Erdal Resit YilmazZeki Sekerci
May 9, 2013·Journal of Gynecologic Oncology·Xiaohuan LiDeshan Zhou
Apr 22, 2014·Journal of Visualized Experiments : JoVE·Alexander SchulzReinhard Bauer
Dec 3, 2014·Neuroscience Letters·V A CarozziA Chiorazzi
Dec 24, 2014·Tissue & Cell·Nazila NiapourMohammad Reza Gholami
Mar 12, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Nivin SharawyMagdy Fouad Youakim
May 20, 2015·Neurobiology of Learning and Memory·Mehmet OzEnver Ahmet Demir
Jun 27, 2015·Experimental Neurobiology·Sithiporn AgthongThuntawat Charoensub
Mar 12, 2016·International Immunopharmacology·Keyvan Amirshahrokhi, Ali-Reza Khalili
Dec 3, 2016·Free Radical Biology & Medicine·Naomi LomeliDaniela A Bota
Mar 17, 2017·Drug and Chemical Toxicology·Abdullah Al MarufJalal Pourahmad
Jun 18, 2017·Frontiers in Molecular Neuroscience·Hana Starobova, Irina Vetter
Jul 22, 2017·Scientific Reports·Satoshi ImaiKazuo Matsubara
Aug 9, 2017·Asian Journal of Psychiatry·Saadati Hakimeh, Sheibani Vahid
Sep 11, 2017·Biophysics Reviews·Eder Ricardo de MoraesLígia Araujo Naves
Jun 5, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ahmed A Abdelsameea, Soad L Kabil
Nov 22, 2018·Frontiers in Pharmacology·Qing-Yu ZhangLing-Dong Kong
Mar 27, 2019·International Journal of Molecular Sciences·Renata ZajączkowskaJerzy Wordliczek
Apr 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yu Zhou, Yimin Qiu

❮ Previous
Next ❯

Citations

Mar 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiMasoud Najafi

❮ Previous
Next ❯

Software Mentioned

ImageJ
Noldus Ethovision® system

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.