The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats

Behavioural Brain Research
Shotaro OtsukaYoshihiro Yoshida

Abstract

Preconditioning exercise can exert neuroprotective effects after stroke. However, the mechanism underlying these neuroprotective effects by preconditioning exercise remains unclear. We investigated the neuroprotective effects of preconditioning exercise on brain damage and the expression levels of the midkine (MK) and brain-derived neurotrophic factor (BDNF) after brain ischemia. Animals were assigned to one of 4 groups: exercise and ischemia (Ex), no exercise and ischemia (No-Ex), exercise and no ischemia (Ex-only), and no exercise and intact (Control). Rats ran on a treadmill for 30 min once a day at a speed of 25 m/min for 5 days a week for 3 weeks. After the exercise program, stroke was induced by a 60 min left middle cerebral artery occlusion using an intraluminal filament. The infarct volume, motor function, neurological deficits, and the cellular expressions levels of MK, BDNF, GFAP, PECAM-1, caspase 3, and nitrotyrosine (NT) were evaluated 48 h after the induction of ischemia. The infarct volume, neurological deficits and motor function in the Ex group were significantly improved compared to that of the No-Ex group. The expression levels of MK, BDNF, GFAP, and PECAM-1 were enhanced in the Ex group compared to the expres...Continue Reading

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Citations

Jun 3, 2016·Frontiers in Molecular Neuroscience·Amanda J Craig, Gary D Housley
Dec 21, 2017·Oxidative Medicine and Cellular Longevity·Kiyoshi KikuchiIkuro Maruyama
Dec 9, 2017·Human & Experimental Toxicology·Yu NaiChao Ren
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Sep 6, 2019·Journal of Neuroscience Research·Ling Yi GuoVoon Wee Yong
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Apr 4, 2019·Neuromolecular Medicine·Stefano PiantaCesar V Borlongan
Feb 6, 2020·Physical Therapy Research·Harutoshi Sakakima
Jun 5, 2020·International Journal of Molecular Sciences·Kiyoshi KikuchiHisaaki Uchikado
Oct 18, 2019·Brain Circulation·Henry ZhangNaoki Tajiri
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Misato OkamuraHiroshi Maejima
Dec 3, 2020·International Journal of Molecular Sciences·Domenico Di RaimondoAntonio Pinto
Dec 16, 2020·International Journal of Molecular Sciences·Márton Richárd SzabóCsaba Csonka
Jan 9, 2021·Frontiers in Aging Neuroscience·Yaqiang LiuChaoyue Meng
May 11, 2020·Journal of the Neurological Sciences·Aniqa B AlamAlvaro Alonso

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