The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury

Progress in Neuro-psychopharmacology & Biological Psychiatry
Thomas RauDavid Poulsen

Abstract

Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disorder (ADHD), obesity and narcolepsy. However, methamphetamine has also become a major drug of abuse worldwide. Under conditions of abuse, which involve the administration of high repetitive doses, methamphetamine can produce considerable neurotoxic effects. However, recent evidence from our laboratory indicates that low doses of methamphetamine can produce robust neuroprotection when administered within 12h after severe traumatic brain injury (TBI) in rodents. Thus, it appears that methamphetamine under certain circumstances and correct dosing can produce a neuroprotective effect. This review addresses the neuroprotective potential of methamphetamine and focuses on the potential beneficial application for TBI.

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Citations

Aug 24, 2016·Expert Opinion on Drug Discovery·Miguel Reyes-Parada, Patricio Iturriaga-Vasquez
Jan 10, 2018·Psychopharmacology·Elena Martín-GonzálezMargarita Moreno
Feb 8, 2019·Frontiers in Neuroscience·Maliheh MohamadpourPeter J Bergold
Feb 17, 2019·Neuroscience Letters·Mayuri ShuklaBruno Vincent
May 6, 2021·International Journal of Molecular Sciences·Sedra AlabedSulie L Chang
Feb 9, 2020·Journal of the Neurological Sciences·Samer El HayekFiras Kobeissy

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