The neurotoxic effects of intrathecal midazolam and neostigmine in rabbits

Anaesthesia and Intensive Care
E DemirelY Kecik

Abstract

In parallel with improvements in understanding pain neurophysiology, many chemicals have recently been investigated for spinal anaesthesia and analgesia. However, studies discussing the effects of these drugs on neural tissue indicate that knowledge about some aspects of neurotoxicity is limited. Forty-nine New Zealand albino rabbits, weighing 2.2 +/- 0.2 kg, were randomly assigned to seven groups of seven animals each. Single dose groups received intrathecally through the atlantooccipital membrane 0.9% saline 1.5 ml; midazolam 100 microg/kg (low dose midazolam group) or 500 microg/kg (high dose midazolam group); neostigmine 10 microg/kg (low dose neostigmine group) or 50 microg/kg (high dose neostigmine group). Two groups had seven days of repeated dosing with either midazolam 100 microg/kg/day (repeat midazolam group) or 10 microg/kg/day neostigmine (repeat neostigmine group). The animals were sacrificed on day 8, and two spinal cord sections from the fourth cervical level and fourth lumbar level were removed and prepared for histopathological study. Transmission electron microscopic evaluations were performed on transverse spinal cord sections by a neuropathologist blinded to the group allocation. Twenty myelinated axons and...Continue Reading

References

Jul 1, 1991·Anesthesiology·J M MalinovskyR Souron
Feb 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I M SchwiegerD R Morel
Apr 16, 1999·Pain·S ErdineN Savci
May 25, 2004·Anesthesia and Analgesia·Adam P TuckerColin S Goodchild
May 25, 2004·Anesthesia and Analgesia·Adam P TuckerColin S Goodchild

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Citations

Jun 28, 2011·Regional Anesthesia and Pain Medicine·Markus F StevensSebastian Braun
Sep 15, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jan ProchazkaLidmila Prochazkova
Aug 23, 2011·Regional Anesthesia and Pain Medicine·Robert WerdehausenMarkus F Stevens
Feb 23, 2017·Acta Cirúrgica Brasileira·Ivan Dias Fernandes PereiraEliana Marisa Ganem
Jan 31, 2020·Saudi Journal of Anaesthesia·G V Krishna PrasadSharma Vipin Jaishree
Oct 1, 2011·International Anesthesiology Clinics·Chad M Brummett, Brian A Williams
Sep 5, 2017·World Journal of Clinical Cases·Amlan SwainDevi Prasad Samaddar

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