PMID: 7539361Mar 1, 1995Paper

The neurotoxic effects of lindane at acute and subchronic dosages

Ecotoxicology and Environmental Safety
A Ortiz Martinez, E Martinez-Conde

Abstract

Lindane (gamma-HCH), a multipurpose organochlorine pesticide, was administered to Rattus norvegicus at acute and subchronic dosages. The dosage given was half that corresponding to LD50 (half the lethal dose). For rats, this is 60 mg/kg of body weight. The acute dose was administered on a single occasion, while the subchronic dosage was administered on 10 occasions over a 30-day period. Six types of behavior pattern based on the neurotoxic register were established for the acute dosage. Significant decreases in the levels of the neurotransmitter dopamine were also found, in similar proportions for both types of dose. The difference between single dose intoxication and poisoning by overlapping doses must be underlined, as the second type may produce the same effects without giving rise to clear symptoms.

Citations

Dec 19, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min ChoiByung Mu Lee
Jun 26, 2007·Neurological Research·Kranthi Kumari NagaPhanithi Prakash Babu
Nov 7, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ashu JohriDevendra Parmar
Aug 18, 2012·Human & Experimental Toxicology·Nk SinghMd Mustafa
Feb 16, 1999·Journal of Applied Toxicology : JAT·A SahooG B Chainy
Oct 23, 2009·Annals of Neurology·Alexis ElbazChristophe Tzourio
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Danijela VucevićOlivera Stanojlović
Sep 21, 2013·Annual Review of Pharmacology and Toxicology·Samuel M Goldman
May 20, 2020·Toxicology Reports·Efthimios DardiotisGeorgios M Hadjigeorgiou
Apr 4, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lang ZhangShan Zhong
Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D ParmarP K Seth
Oct 24, 2001·Journal of Biochemical and Molecular Toxicology·D K ChowdhuriD K Saxena

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