PMID: 2100318Dec 1, 1990Paper

The neurotoxicology and pathology of organomercury, organolead, and organotin

The Journal of Toxicological Sciences
L W Chang

Abstract

The toxicities of many metals, such as mercury and lead, are known to man since the dawn of civilization. Organic compounds of some heavy metals are known to have a particular toxic impact on the central nervous system. Organomercury, particularly alkyl-mercuric compounds (e.g. methylmercury), has a selective effect on the granule cells of the cerebellum, the nerve cells of the calcarine cortex, and the sensory neurons in the dorsal root ganglia. The well known Minamata Bay disease is the result of a massive epidemic episode of human exposure to alkylmercury contaminated food sources. Mental retardation and other developmental defects are also known to be a consequence of exposure to this toxic metal. Organic lead compounds have been employed as gasoline additives and in other industrial purposes. Unlike its inorganic counterpart, organolead compounds have a more prominent impact on the central nervous system. Pathological changes of the brain stem neurons have been described. Organotin compounds have been used in plastic industries and as agricultural chemicals. Both trimethyl and triethyl tin compounds are found to be extremely neurotoxic. Despite the similarity of their chemical structures, trimethyl and triethyl tins have a...Continue Reading

Citations

Dec 16, 2005·Journal of Biomedical Materials Research. Part a·Nasreen BanuRumi Sawada
Aug 16, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jinwook KimChangjong Moon
Feb 11, 2000·Toxicologic Pathology·M A PhilbertK R Reuhl
Jul 17, 2007·Canadian Journal of Physiology and Pharmacology·Philippe GirardJean-Marie Gillardin
Sep 1, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Chen LiYong Tang
Feb 4, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chang Ho Hwang
Jul 21, 2009·Prehospital and Disaster Medicine·David J BakerVirginia S G Murray
Sep 23, 2014·The Journal of Toxicological Sciences·Hironori KandaYoshito Kumagai
Mar 20, 2016·Molecular Pharmacology·Cristina Esteva-FontA S Verkman
Feb 11, 2000·Toxicologic Pathology·D C Dorman
Nov 28, 2013·Neurotoxicity Research·Senthilvelan ManoharRichard Salvi
Mar 13, 2013·Bulletin of Environmental Contamination and Toxicology·Xiaojiang TangXuefeng Ren
Dec 20, 2008·Journal of Occupational Health·Rustam SadykovAzhar Zhubanova
Aug 21, 2007·Archives of Pharmacal Research·Yu Mi KimMyung Koo Lee
Sep 17, 2014·Journal of Applied Toxicology : JAT·Xuefeng RenXiaojiang Tang
Mar 23, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Brandon K WillsMichael Miller
Mar 21, 2012·Nature Reviews. Neurology·Kelly L Bertram, David R Williams
Nov 3, 2016·Biological & Pharmaceutical Bulletin·Yoko IdotaTakuo Ogihara
Jun 7, 2018·Frontiers in Endocrinology·Carolina Monteiro de Lemos BarbosaJones B Graceli
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hesham S ElsabbaghOsama S El-tawil
Sep 4, 2015·Chemical Reviews·Erwan Le GrognecJean-Paul Quintard

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