PMID: 8965654Mar 1, 1996Paper

The neurotoxin MPTP increases calbindin-D28k levels in mouse midbrain dopaminergic neurons

Brain Research. Molecular Brain Research
M C NgD C German

Abstract

The calcium-binding protein calbindin-D28k (CALB) has been localized in high concentrations in several neuronal populations within the central nervous system (CNS) and is believed to act as an intracellular calcium (Ca2+) buffer. There has been much interest and speculation concerning its potential neuroprotective function. However, there is little direct evidence linking CALB content of individual neurons to Ca2+ buffering ability, resistance to Ca(2+)-mediated excitotoxicity, or vulnerability to Ca(2+)-mediated degeneration. It is necessary to demonstrate these relationships on a cellular level so that more definitive conclusions can be made. We have utilized immunocytochemical and Western blot techniques to determine whether cellular CALB content is altered in the nucleus A10 dopaminergic region of the midbrain following administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Our data demonstrate a significant increase in the CALB content of nucleus A10 neurons (up to 227 +/- 23% above control) 3 and 6 h after MPTP treatment. CALB elevation demonstrated both time and dosage dependence as 6-h groups exhibited larger increases than 3-h groups, and a 60 mg/kg dosage induced a larger increase than a...Continue Reading

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Citations

Jun 16, 2000·Molecular and Cellular Endocrinology·V R AgarwalE R Simpson
Nov 9, 2007·The Journal of Comparative Neurology·Qing XuStewart A Anderson
May 23, 2006·Brain Research·Marianne M Zupanc, Günther K H Zupanc
Dec 19, 2014·Frontiers in Neuroanatomy·Iria G Dopeso-ReyesJose L Lanciego
May 6, 2019·International Journal of Molecular Sciences·Richard FairlessRicarda Diem

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