The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.

The Journal of Experimental Medicine
C A DahindenM Baggiolini

Abstract

IgE-independent mediator release from basophils is considered an important event in inflammation, particularly in nonallergic immediate hypersensitivity and in allergic late-phase reactions. This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1. Thus, the sequential action of two pure cytokines can promote basophils mediator release. In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions.

References

Aug 1, 1989·The Journal of Experimental Medicine·Y KurimotoC A Dahinden
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H SaitoT Ishizaka
Mar 15, 1988·Biochemical and Biophysical Research Communications·H GregoryE Christophers
Jun 5, 1987·Science·S C Clark, R Kamen
Dec 16, 1987·Biochemical and Biophysical Research Communications·A WalzM Baggiolini
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T YoshimuraE J Leonard
Apr 1, 1984·The Journal of Clinical Investigation·R A Lewis, K F Austen

❮ Previous
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Citations

Jul 1, 1992·Journal of Clinical Immunology·T N Liao, K H Hsieh
Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Oct 1, 1990·Immunology Today·A Mantovani
Mar 1, 1994·Immunology Today·M Baggiolini, C A Dahinden
Jul 1, 1996·Critical Reviews in Oncology/hematology·C Denzlinger
Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A J WeidoT C Sim
Nov 15, 2008·Nature Immunology·Booki Min
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S C BischoffC A Dahinden
Nov 1, 1990·The Journal of Experimental Medicine·K HiraiT Miyamoto
Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
May 1, 1992·The Journal of Experimental Medicine·S C BischoffC A Dahinden
Feb 1, 1994·The Journal of Experimental Medicine·C A DahindenM Baggiolini
Sep 11, 2009·Current Opinion in Hematology·Peter Valent, Clemens A Dahinden
Jan 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R E O'HehirJ R Lamb
Dec 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J DouglassS T Holgate
Aug 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KunaA P Kaplan
Apr 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P GossetA B Tonnel
Dec 1, 1994·Allergy·A J WardlawF A Symon
Aug 1, 1995·Experimental Dermatology·A P KaplanS R Reddigari
Feb 1, 1994·Archives of Disease in Childhood·H Kimata, I Lindley
Aug 24, 1999·Thorax·K F Chung, P J Barnes
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·S S SalviA J Frew
Feb 1, 1992·The American Review of Respiratory Disease·J GauldieJ Denburg
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·S M PageL L Thomas
Jun 1, 1990·American Journal of Respiratory Cell and Molecular Biology·E J Leonard, T Yoshimura
Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·S KawaboriJ Dolovich
May 1, 1990·The Journal of Clinical Investigation·M L BaezaA P Kaplan
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Z SzépfalusiR Urbanek
Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y TanimotoI Kimura
Mar 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Shute
Nov 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y OkayamaM K Church
Dec 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R SehmiA B Kay
Jan 1, 1993·Cancer Investigation·A Lindemann, R Mertelsmann

❮ Previous
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