The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.

Journal of Leukocyte Biology
Agnes Dahlstrand RudinJohan Bylund

Abstract

In recent years, the concept of distinct subpopulations of human neutrophils has attracted much attention. One bona fide subset marker, exclusively expressed by a proportion of circulating neutrophils in a given individual, and therefore dividing neutrophils in two distinct subpopulations, is the glycoprotein CD177. CD177 is expressed on the plasma and granule membranes of 0-100% of circulating neutrophils depending on the donor. Several in vitro studies have linked CD177 to neutrophil transmigration, yet very few have looked at the role of CD177 for tissue recruitment in vivo. We investigate whether the CD177+ and CD177- neutrophil subsets differ in their propensity to migrate to both aseptic- and microbe-triggered inflamed human tissues. Microbe-triggered neutrophil migration was evaluated in samples of gingival crevicular fluid (GCF) from patients with periodontitis, whereas neutrophil migration to aseptic inflammation was evaluated in synovial fluid from patients with inflammatory arthritis, as well as in exudate from experimental skin chambers applied on healthy donors. We found that the proportion of CD177+ neutrophils was significantly higher in GCF from patients with periodontitis, as compared to blood from the same ind...Continue Reading

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Citations

Aug 15, 2020·Journal of Leukocyte Biology·Julia Volkmann, Sibylle von Vietinghoff
Aug 9, 2020·Journal of Leukocyte Biology·Agnes Dahlstrand Rudin, Johan Bylund
Feb 6, 2021·Frontiers in Cellular and Infection Microbiology·Agnes Dahlstrand RudinJohan Bylund

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