The neutrophil-to-lymphocyte ratio is associated with bacteremia in older adults visiting the emergency department with urinary tract infections

Aging Clinical and Experimental Research
Woon Jeong LeeSungyoup Hong

Abstract

We evaluated the clinical features of older adults visiting the emergency department (ED) with urinary tract infections (UTIs), and the diagnostic utility of the neutrophil-to-lymphocyte ratio (NLR) in terms of identifying bacteremia. In total, 479 older adults admitted with UTIs via the ED between January 2010 and December 2015 were retrospectively reviewed. We recorded age, sex, comorbidities, body temperature, clinical findings, and initial laboratory results, including the NLR. A UTI with bacteremia was identified in 186 (38.8%) older adults. Bacteremia was associated with a longer hospital stay (median 10 vs. 8 days, p < 0.001). NLRs and C-reactive protein, blood urea nitrogen and creatinine levels were significantly higher in the bacteremia group than in the non-bacteremia group (p < 0.001, p = 0.016, p = 0.008, and p = 0.011, respectively). The area under the curve for the NLR was 0.624 (95% CI = 0.579-0.668, p < 0.001), and the cutoff was 9.0 (sensitivity 74.2, specificity 49.2%). Independent risk factors for bacteremia were an NLR ≥ 9 and fever ≥ 39 °C (OR 2.43, OR 2.75: p < 0.001, p < 0.001, respectively). Bacteremia was associated with a longer hospital stay in older adults with UTIs, in whom the initial NLR and high...Continue Reading

References

Mar 1, 1997·The American Journal of Emergency Medicine·A G PinsonJ B Schorling
Jun 28, 2000·American Journal of Obstetrics and Gynecology·D A WingL K Millar
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·María VelascoJosé Mensa
Apr 23, 2005·The Journal of Infection·Sari TalAlexander Gurevich
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Oct 10, 2008·Journal of Clinical Microbiology·James H TabibianDavid A Haake
Jun 29, 2010·Archives of Gerontology and Geriatrics·Bum Sik ChinJune Myung Kim
Nov 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Cornelis P C de JagerPeter C Wever
Aug 16, 2011·The American Journal of Geriatric Pharmacotherapy·S James Matthews, Jason W Lancaster
Apr 26, 2013·International Urology and Nephrology·Katsumi ShigemuraMasato Fujisawa
May 13, 2014·European Journal of Internal Medicine·Ana EsparciaJosé M Nogueira
Nov 5, 2015·Angiology·Sevket BaltaAtila Iyisoy
Jul 10, 2016·Clinics in Geriatric Medicine·Lindsay E Nicolle
Sep 22, 2016·The American Journal of the Medical Sciences·Arturo ArteroJosé M Nogueira
Nov 4, 2016·The American Journal of Emergency Medicine·Sung Yeon HwangMin Seob Sim
Nov 20, 2016·Internal and Emergency Medicine·Antonio LaluezaJosé María Aguado

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