The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Ryoichi MiyamotoMasayoshi Yamamoto

Abstract

The preoperative neutrophil-to-lymphocyte ratio (NLR) is a well-known prognostic marker for gastric cancer patients. However, the utility of the NLR in predicting short-term outcomes in gastric cancer patients remains unclear. Here, we investigated whether the preoperative NLR is a predictor of short-term outcomes in gastric cancer patients. We retrospectively evaluated 154 consecutive gastric cancer patients. We compared the perioperative outcomes and median survival times (MSTs). In particular, for stage II/III (UICC, 7th edition) gastric cancer patients, we compared median disease-free survival time (MDFST) between the low- and high-NLR groups. Between the low-NLR group (n = 110) and the high-NLR group (n = 44), significant differences were observed in perioperative outcomes, including postoperative complications (3 (2.7%) vs. 5 (11.3%); p = 0.015), intraoperative blood loss (158 ± 168 g vs. 232 ± 433 g; p = 0.022), and intraoperative blood transfusions (0 vs. 3 (6.8%); p = 0.042). MSTs and MDFSTs were also significantly different (812 vs. 594 days, p = 0.04; and 848 vs. 475 days, p = 0.03, respectively). Multivariate analysis identified the NLR (hazard ratio [HR], 2.015; p = 0.004), Glasgow Prognostic Score (GPS) (HR, 1.533...Continue Reading

Associated Clinical Trials

Citations

Nov 1, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jun LuPing Li
Oct 18, 2019·Journal of Anesthesia·Jun AsadaMasahiko Kawaguchi
Feb 6, 2020·Annals of Gastroenterological Surgery·Yusuke IshibashiHideki Ueno
Apr 14, 2020·Cancer Management and Research·Chen ZhengXiang Zhao
Jul 15, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·V RodriguesM Armengol
Jul 20, 2020·Neuroscience Letters·Hong JinChun-Feng Liu
Oct 30, 2020·Cancer Management and Research·Razan MansourMaysa Al-Hussaini
Jan 14, 2021·Journal of Clinical Medicine·Tomonari Kinoshita, Taichiro Goto
Mar 2, 2021·Annals of Medicine and Surgery·René M Palacios HuatucoMatías Parodi
May 1, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mirinae KimYoung-Hoon Park
Jun 22, 2021·Cancer Biomarkers : Section a of Disease Markers·Murat Yildirim, Bulent Koca
Aug 27, 2021·Neuropsychiatric Disease and Treatment·Yi ZhaoYanjie Jia
Sep 28, 2021·Frontiers in Oncology·Guang-Liang ChenWei-Jian Guo
Jan 14, 2022·Immunologic Research·Jane Kasten-Jolly, David A Lawrence

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