The new 2011 recommendations of the National Institute on Aging and the Alzheimer's Association on diagnostic guidelines for Alzheimer's disease: Preclinal stages, mild cognitive impairment, and dementia

Revue neurologique
B CroisileAlzheimer Association

Abstract

Criteria for the clinical diagnosis of Alzheimer's disease (AD) were established in 1984, and they needed to be updated and revised, in vue of the scientific knowledge acquired over the last decades. The National Institute on Aging (NIA) and the Alzheimer's Association (AA) sponsored a series of advisory round table meetings to establish a revision of diagnostic and research criteria for AD. The workgroups reviewed the biomarker, epidemiological, and neuropsychological evidence, and proposed conceptual frameworks as well as operational research criteria based on the prevailing scientific evidence to date. Three preclinical stages of AD were proposed: asymptomatic amyloidosis, asymptomatic amyloidosis+neurodegeneration, amyloidosis+neurodegeneration+subtle cognitive decline. The preclinical workgroup developed recommendations to determine the factors, which best predict the risk of progression from normal cognition to mild cognitive impairment (MCI) and AD dementia. It is necessary to refine these models with longitudinal clinical research studies. The workgroups on MCI and AD dementia sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsycho...Continue Reading

Citations

Jun 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Robert BriggsDesmond O'Neill
Dec 4, 2014·Metabolism: Clinical and Experimental·Theodore B VanItallie
Oct 13, 2017·Aging Clinical and Experimental Research·Linhui ChenYu Jin
Apr 3, 2019·Journal of Neuropathology and Experimental Neurology·Yanqing LiQinwen Mao
Jul 1, 2017·The Journal of International Medical Research·Demet Ilhan AlginIlknur Ak Sivrioz
May 22, 2018·Journal of Alzheimer's Disease : JAD·Jessica BourginPascal Hot

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