The new Alzheimer's criteria in a naturalistic series of patients with mild cognitive impairment.

Journal of Neurology
Samantha GalluzziTranslational Outpatient Memory Clinic Working Group

Abstract

To test the validity of the new diagnostic criteria for Alzheimer's disease (AD) in a naturalistic series of patients with mild cognitive impairment (MCI). Ninety consecutive MCI patients were enrolled in a longitudinal study on the natural history of cognitive impairment. Medial temporal (MT) atrophy on MRI was defined as hippocampal volume below the fifth percentile of the distribution in healthy elders, abnormal CSF was based on Sjogren's cutoffs for Abeta42 and tau, and temporoparietal hypometabolism on 18F-FDG PET based on Herholz's t sum score. Patients were followed clinically to detect conversion to AD (MCI-AD), non-AD dementia (MCI-nAD), or no conversion (MCI-NC). The 24 MCI-AD and 15 MCI-nAD patients had sociodemographic, clinical, and neuropsychological baseline features similar to the 51 MCI-NC patients. All MCI patients with MT atrophy converted to AD, as did all those with abnormal CSF, but only 48 and 35% of those without MT atrophy or abnormal CSF converted (p on logrank test = 0.0007 and 0.001). Prediction of AD conversion was enhanced when positivity to either MT atrophy or abnormal CSF was considered, with only 15% of those MCI patients negative on both converting to AD (p < 0.0005). Markers were not predicti...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1993·The British Journal of Clinical Psychology·D De LeoM Trabucchi
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Nov 16, 2001·Archives of Neurology·G M McKhannUNKNOWN Work Group on Frontotemporal Dementia and Pick's Disease
Jul 24, 2002·Neurology·D A BennettJ Bach
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Michael D Devous
Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Apr 26, 2005·Aging Clinical and Experimental Research·Lorena BrescianiGiovanni B Frisoni
Aug 15, 2006·Journal of Neural Transmission·M BiblJ Wiltfang
Feb 13, 2007·Brain : a Journal of Neurology·Giovanni B FrisoniPaul M Thompson
May 1, 2008·The British Journal of Radiology·K HerholzM Jones
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Harald HampelKaj Blennow
Nov 18, 2008·Neurobiology of Disease·Rebecca Craig-SchapiroDavid M Holtzman
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Miroslaw BrysMony J de Leon
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 4, 2009·Annals of Clinical Biochemistry·N A VerweyM A Blankenstein
Jun 30, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Giovanni B FrisoniCristina Geroldi
Jul 23, 2009·JAMA : the Journal of the American Medical Association·Niklas MattssonKaj Blennow
Jul 29, 2009·Neurology·P VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 20, 2009·Current Alzheimer Research·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Dec 5, 2009·Aging Clinical and Experimental Research·Samantha GalluzziGiovanni B Frisoni
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Feb 9, 2010·Nature Reviews. Neurology·Giovanni B FrisoniPaul M Thompson

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Citations

Apr 25, 2012·Journal of Neurology·Basar BilgicMurat Emre
Oct 17, 2012·Journal of Neurology·Samantha GalluzziUNKNOWN Translational Outpatient Memory Clinic Working Group
Nov 15, 2012·International Psychogeriatrics·John T O'Brien
Aug 25, 2012·Biomarkers in Medicine·Pieter Jelle VisserHermann-Josef Gertz
Aug 24, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·J A Monge ArgilésC Leiva Santana
Sep 18, 2013·Revue neurologique·B DuboisH Hampel
May 7, 2011·International Journal of Alzheimer's Disease·Meredith N BraskiePaul M Thompson
Aug 31, 2011·Journal of Biomedicine & Biotechnology·Roberta GhidoniLuigi F Agnati
Jun 29, 2011·Neuro-degenerative Diseases·Roberta GhidoniEnzo Emanuele
Jan 30, 2015·The Cochrane Database of Systematic Reviews·Nadja SmailagicChristos Sachpekidis
Apr 25, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Anuraag R KansalStanmira Krotneva
Aug 26, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martina BocchettaGiovanni B Frisoni
Aug 21, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiUNKNOWN European Federation of the Neurologic Societies
Mar 13, 2014·Journal of Internal Medicine·J C MorrisB Dubois
Mar 4, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Giovanni B Frisoni, Clifford R Jack
Apr 14, 2017·Zeitschrift für Gerontologie und Geriatrie·Ingo KilimannStefan J Teipel

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