The New Direct Antiviral Agents and Hepatitis C in Thoracic Transplantation: Impact on Donors and Recipients

Current Transplantation Reports
Robert L Gottlieb, Shelley A Hall

Abstract

The landscape of abdominal organ transplantation has been altered by the emergence of curative direct-acting antiviral agents for hepatitis C. Expansion of the thoracic donor pool to include the hearts and the lungs from hepatitis C-positive donors holds promise to increase available donor organs. Case reports have documented separate lung and heart transplant patients who acquired, and then were cured of, donor-derived hepatitis C using these newer, more effective therapies. Single sites and national consortia are underway to help make this approach part of the standard-of-care. Pangenotypic therapies may simplify the paradigm. Organs from donors with active hepatitis C viremia are likely suitable for transplant as long as the organ is otherwise acceptable. Best-practices for "informed-risk" transplant include a team-based approach and a selection of the antiviral regimen based on insurer's formulary, potential drug interactions, and genotype.

Associated Clinical Trials

References

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Citations

May 9, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Justin N TawilMichael L Boisen
Dec 19, 2018·Circulation. Heart Failure·Yasbanoo MoayediKiran K Khush

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Methods Mentioned

BETA
PCR
pharmacotherapy

Clinical Trials Mentioned

NCT03146741
NCT03086044
NCT03382847
NCT03026023
NCT03383419
NCT03112044

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