The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii

Antimicrobial Agents and Chemotherapy
Juliette R K WipfVincent Perreten

Abstract

Genome alignment of a macrolide, lincosamide, and streptogramin B (MLSB)-resistant Staphylococcus fleurettii strain with an MLSB-susceptible S. fleurettii strain revealed a novel 11,513-bp genomic island carrying the new erythromycin resistance methylase gene erm(45). This gene was shown to confer inducible MLSB resistance when cloned into Staphylococcus aureus. The erm(45)-containing island was integrated into the housekeeping gene guaA in S. fleurettii and was able to form a circular intermediate but was not transmissible to S. aureus.

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Citations

Jul 28, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Xiaoxue Wang, Thomas K Wood
Apr 26, 2017·Antimicrobial Agents and Chemotherapy·Juliette R K WipfVincent Perreten
Jun 8, 2017·Antibiotics·Maria Angeles ArgudínSandrine Roisin
Oct 9, 2020·Expert Review of Anti-infective Therapy·Sophie Reissier, Vincent Cattoir
Oct 31, 2020·Environmental Geochemistry and Health·Zibo LinQiyan Feng
Jul 12, 2018·Microbiology Spectrum·Stefan SchwarzJianzhong Shen

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