The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

The Journal of General Virology
Svenja WolffStephan Becker

Abstract

The Arenaviridae is a diverse and growing family of viruses that already includes more than 25 distinct species. While some of these viruses have a significant impact on public health, others appear to be non-pathogenic. At present little is known about the host cell responses to infection with different arenaviruses, particularly those found in the New World; however, apoptosis is known to play an important role in controlling infection of many viruses. Here we show that infection with Tacaribe virus (TCRV), which is widely considered the prototype for non-pathogenic arenaviruses, leads to stronger induction of apoptosis than does infection with its human-pathogenic relative Junín virus. TCRV-induced apoptosis occurred in several cell types during late stages of infection and was shown to be caspase-dependent, involving the activation of caspases 3, 7, 8 and 9. Further, UV-inactivated TCRV did not induce apoptosis, indicating that the activation of this process is dependent on active viral replication/transcription. Interestingly, when apoptosis was inhibited, growth of TCRV was not enhanced, indicating that apoptosis does not have a direct negative effect on TCRV infection in vitro. Taken together, our data identify and chara...Continue Reading

References

Oct 1, 1975·Journal of Virology·J B GliedmanD T Brown
Nov 1, 1987·Journal of Medical Virology·G CarballalM C Weissenbacher
Oct 1, 1982·Journal of Clinical Microbiology·L H ElliottK M Johnson
Jan 1, 1996·Journal of Virology·C W OlsenV S Hinshaw
May 1, 1996·Virology·M D BowenS T Nichol
Mar 1, 1997·Journal of Virology·J G Teodoro, P E Branton
Aug 26, 1998·Trends in Cell Biology·D Green, G Kroemer
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Jan 23, 1999·Oncogene·G NuñezN Inohara
Jun 25, 1999·Cell Death and Differentiation·C Borner, L Monney
Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
May 22, 2002·The Journal of Biological Chemistry·Michael BitzerUlrich M Lauer
Jun 21, 2002·The Journal of General Virology·Stewart Hay, George Kannourakis
Nov 15, 2002·Journal of Cell Science·Céline CandéGuido Kroemer
Mar 26, 2003·Cell Death and Differentiation·U FischerK Schulze-Osthoff
May 30, 2003·The EMBO Journal·Walter J WurzerStephan Ludwig
Jun 14, 2003·TheScientificWorldJournal·David J Granville, Roberta A Gottlieb
Jul 29, 2004·Journal of Virology·Ernesto MéndezCarlos F Arias
Aug 18, 2004·Biochemical Pharmacology·A Ivana Scovassi, Marc Diederich
Oct 16, 2004·The Journal of General Virology·Xiao-Dong LiAntti Vaheri
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·M S IordanovB E Magun
Nov 3, 2005·The FEBS Journal·Po-ki Ho, Christine J Hawkins
Nov 4, 2006·Cell Death and Differentiation·S Kumar
Nov 4, 2006·Cell Death and Differentiation·J C Timmer, G S Salvesen
May 31, 2007·BMC Microbiology·Malte C KleinschmidtJindrich Cinatl
Nov 28, 2008·Journal of Thrombosis and Haemostasis : JTH·K J ClemetsonUNKNOWN Registry of Exogenous Hemostatic Factors of SSC of the ISTH
Jan 9, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marc RemacleJochen Werner
Jan 29, 2010·Journal of Virology·Allison GrosethStephan Becker
Apr 3, 2010·The EMBO Journal·Saurabh ChattopadhyayGanes C Sen

❮ Previous
Next ❯

Citations

Jan 11, 2019·Journal of Virology·Giulia TorrianiStefan Kunz
Mar 29, 2019·Frontiers in Immunology·Morgan E Brisse, Hinh Ly
Oct 13, 2020·PLoS Pathogens·Julia HolzerlandAllison Groseth
Oct 31, 2017·Microbes and Infection·Bjoern Meyer, Allison Groseth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis