The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Chemical Reviews
Timothy C JohnstoneStephen J Lippard

Abstract

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown, and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this Review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore nonclassical platinum(II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-threat agents, and photoactivatable platinum(IV) complexes. Nanoparticles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carb...Continue Reading

References

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·J A DeBin, G R Strichartz
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R de WitG Stoter
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·L PendyalaP J Creaven
Apr 1, 1989·American Journal of Clinical Oncology·D J MeisnerB Poiesz
Oct 1, 1989·Journal of Medicinal Chemistry·N FarrellN P Johnson
Feb 24, 1989·Science·M E BianchiG Paonessa
Aug 1, 1988·European Journal of Cancer & Clinical Oncology·M ClavelH M Pinedo
Sep 1, 1988·Investigational New Drugs·F P PaolozziS Ginsberg
Jan 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C SessaH Pinedo
Jan 1, 1987·Advances in Enzyme Regulation·K S VitolsF M Huennekens
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K W JennetteW R Bauer
Feb 1, 1967·Journal of Bacteriology·B RosenbergJ Drobnik
Apr 26, 1969·Nature·B RosenbergV H Mansour
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J BrouwerJ Reedijk
Oct 1, 1994·Anti-cancer Drugs·T J O'RourkeG M Clark
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C HuangA Sancar
Feb 19, 1993·Journal of Medicinal Chemistry·M ColucciaG Natile
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V Brabec, M Leng
Jun 1, 1993·British Journal of Cancer·D P Gately, S B Howell
Dec 22, 1995·Chemico-biological Interactions·M ColucciaG Natile
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·F I RaynaudK R Harrap
Jan 15, 1996·Nucleic Acids Research·V BrabecG Natile

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Citations

Jun 29, 2016·Journal of Inorganic Biochemistry·Alessio TerenziWalter Berger
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gregoire F Le BrasClaudia D Andl
Sep 8, 2016·Inorganic Chemistry·David PollakKlaus-Richard Pörschke
Nov 23, 2016·Future Medicinal Chemistry·Mickaël MarloyeFrançois Dufrasne
Feb 6, 2017·The Journal of Physical Chemistry Letters·Joanna Czapla-MasztafiakJacinto Sá
Feb 15, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Xu DongChristian G Schäfer
Feb 15, 2017·Journal of Medicinal Chemistry·Dorian M Cheff, Matthew D Hall
Apr 11, 2017·Future Medicinal Chemistry·Sotirios KatsamakasVasiliki Sarli
Apr 25, 2017·Metallomics : Integrated Biometal Science·O HrabinaViktor Brabec
Apr 8, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yang HuFu-Jian Xu
May 5, 2017·Organic Letters·Nuria Rodríguez-VázquezJuan R Granja
May 17, 2017·Advanced Healthcare Materials·Yunlu DaiFrank Caruso
May 18, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Benjamin W J HarperDan Gibson
May 24, 2017·Chemical Communications : Chem Comm·Khushbu SinghAshis K Patra
May 13, 2017·Inorganic Chemistry·Raja MitraKlaus-Richard Pörschke
Jul 6, 2016·Angewandte Chemie·Gregory ThiabaudJonathan L Sessler
Nov 25, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Koushambi Mitra
Dec 22, 2016·Chemical Communications : Chem Comm·Weiqi ZhangChing-Hsuan Tung
Feb 6, 2017·Drug Delivery·Orazio VittorioGiuseppe Cirillo
Dec 10, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Davide CorintiSimonetta Fornarini
Apr 21, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Marta SolerMiquel Costas
May 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·V VenkateshPeter J Sadler
Jun 22, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Jingran DongTiesheng Shi
Jun 22, 2017·Inorganic Chemistry·Alessandra CurciNicola Margiotta
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ming HuBengang Xing
Jul 12, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Anton A ShushakovEvgeni M Glebov
Jul 12, 2017·Chemical Society Reviews·Deborah PedonePier Paolo Pompa
Jun 27, 2017·Chemical Biology & Drug Design·Young CheunSeongmin Lee

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