The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Chemical Reviews
Timothy C JohnstoneStephen J Lippard


The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown, and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this Review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore nonclassical platinum(II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-threat agents, and photoactivatable platinum(IV) complexes. Nanoparticles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carb...Continue Reading


Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·J A DeBin, G R Strichartz
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R de WitG Stoter
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·L PendyalaP J Creaven
Apr 1, 1989·American Journal of Clinical Oncology·D J MeisnerB Poiesz
Oct 1, 1989·Journal of Medicinal Chemistry·N FarrellN P Johnson
Feb 24, 1989·Science·M E BianchiG Paonessa
Aug 1, 1988·European Journal of Cancer & Clinical Oncology·M ClavelH M Pinedo
Sep 1, 1988·Investigational New Drugs·F P PaolozziS Ginsberg
Jan 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C SessaH Pinedo
Jan 1, 1987·Advances in Enzyme Regulation·K S VitolsF M Huennekens
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K W JennetteW R Bauer
Feb 1, 1967·Journal of Bacteriology·B RosenbergJ Drobnik
Apr 26, 1969·Nature·B RosenbergV H Mansour
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J BrouwerJ Reedijk
Oct 1, 1994·Anti-cancer Drugs·T J O'RourkeG M Clark
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C HuangA Sancar
Feb 19, 1993·Journal of Medicinal Chemistry·M ColucciaG Natile
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V Brabec, M Leng
Jun 1, 1993·British Journal of Cancer·D P Gately, S B Howell
Dec 22, 1995·Chemico-biological Interactions·M ColucciaG Natile
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·F I RaynaudK R Harrap
Jan 15, 1996·Nucleic Acids Research·V BrabecG Natile

❮ Previous
Next ❯


Jun 29, 2016·Journal of Inorganic Biochemistry·Alessio TerenziWalter Berger
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gregoire F Le BrasClaudia D Andl
Sep 8, 2016·Inorganic Chemistry·David PollakKlaus-Richard Pörschke
Nov 23, 2016·Future Medicinal Chemistry·Mickaël MarloyeFrançois Dufrasne
Feb 6, 2017·The Journal of Physical Chemistry Letters·Joanna Czapla-MasztafiakJacinto Sá
Feb 15, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Xu DongChristian G Schäfer
Feb 15, 2017·Journal of Medicinal Chemistry·Dorian M Cheff, Matthew D Hall
Apr 11, 2017·Future Medicinal Chemistry·Sotirios KatsamakasVasiliki Sarli
Apr 25, 2017·Metallomics : Integrated Biometal Science·O HrabinaViktor Brabec
Apr 8, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yang HuFu-Jian Xu
May 5, 2017·Organic Letters·Nuria Rodríguez-VázquezJuan R Granja
May 17, 2017·Advanced Healthcare Materials·Yunlu DaiFrank Caruso
May 18, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Benjamin W J HarperDan Gibson
May 24, 2017·Chemical Communications : Chem Comm·Khushbu SinghAshis K Patra
May 13, 2017·Inorganic Chemistry·Raja MitraKlaus-Richard Pörschke
Jul 6, 2016·Angewandte Chemie·Gregory ThiabaudJonathan L Sessler
Nov 25, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Koushambi Mitra
Dec 22, 2016·Chemical Communications : Chem Comm·Weiqi ZhangChing-Hsuan Tung
Feb 6, 2017·Drug Delivery·Orazio VittorioGiuseppe Cirillo
Dec 10, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Davide CorintiSimonetta Fornarini
Apr 21, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Marta SolerMiquel Costas
May 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·V VenkateshPeter J Sadler
Jun 22, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Jingran DongTiesheng Shi
Jun 22, 2017·Inorganic Chemistry·Alessandra CurciNicola Margiotta
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ming HuBengang Xing
Jul 12, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Anton A ShushakovEvgeni M Glebov
Jul 12, 2017·Chemical Society Reviews·Deborah PedonePier Paolo Pompa
Jun 27, 2017·Chemical Biology & Drug Design·Young CheunSeongmin Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Inorganic Chemistry
Timothy C JohnstoneStephen J Lippard
Anti-cancer Agents in Medicinal Chemistry
Xiaoyong Wang
Current Opinion in Chemical Biology
Jennifer S Butler, Peter J Sadler
Chemistry : a European Journal
Benjamin W HarperJanice R Aldrich-Wright
© 2021 Meta ULC. All rights reserved