The next generation of therapy for multiple myeloma: a review of ongoing clinical trials utilizing ClinicalTrials.gov

Future Oncology
Peter BarthJohn L Reagan

Abstract

The therapeutic armamentarium for multiple myeloma has grown significantly over the past decade. We characterized ongoing multiple myeloma clinical trials utilizing ClinicalTrials.gov . A search of ClinicalTrials.gov on 21 April 2017 returned 239 therapeutic interventional trials in multiple myeloma. A majority (84.1%) of trials are early-phase (I/II). Immunotherapies are significantly more likely to be studied in Phase I trials than Phase II trials (p = 0.0049). Primary sponsor (academic, cooperative group, industry) is significantly associated with phase of trial (p = 0.0334). Quality of life assessment is included as a secondary objective in only 10.1% of trials. Areas of need are continued advancement of immunotherapies, late-phase studies utilizing a triplet control group, and an objective focus on quality of life.

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Citations

May 16, 2019·Open Biology·Ricky M TriggSuzanne D Turner
Dec 7, 2018·British Journal of Cancer·Katharina KriegsmannMichael Hundemer
May 13, 2021·Current Medical Research and Opinion·Jéssica Soares MaltaCristiane Aparecida Menezes de Pádua
May 29, 2021·Journal of Psychiatric Research·Ashley N SiegelJoshua D Rosenblat

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