The next wave of recombinant and synthetic anticancer vaccines

Seminars in Cancer Biology
K R Irvine, N P Restifo

Abstract

The identification of tumor-associated antigens (TAA) recognized by T lymphocytes makes the development of antigen-specific synthetic and recombinant vaccines possible. The expression of TAA within a recombinant vector increases control over the kinetics and quantity, the molecular form, and the subcellular location of the immunogen delivered. The next generation of antitumor vaccines employs cytokines and costimulatory molecules expressed in concert with TAA that are capable of augmenting the activation and proliferation of antitumor immune responses. The ultimate goal of these new strategies, the treatment of established cancer, is now being realized in animal models.

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Citations

Jan 1, 1997·Immunologic Research·Y Kawakami, S A Rosenberg
Aug 24, 2012·Expert Review of Vaccines·David M Lubaroff
Sep 10, 2003·International Reviews of Immunology·Jennifer D LewisRobert K Bright
Feb 10, 2018·Immunotherapy·Md Kamal HossainVasso Apostolopoulos
Oct 9, 2013·Expert Review of Vaccines·Adrian BotKent A Smith

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Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.