The NF-κB Activating Pathways in Multiple Myeloma

Biomedicines
Payel RoyS Basak

Abstract

Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis of multiple myeloma. Tumor microenvironment-derived cytokines and cancer-associated genetic mutations signal through the canonical as well as the non-canonical arms to activate the NF-κB system in myeloma cells. In fact, frequent engagement of both the NF-κB pathways constitutes a distinguishing characteristic of myeloma. In turn, NF-κB signaling promotes proliferation, survival and drug-resistance of myeloma cells. In this review article, we catalog NF-κB activating genetic mutations and microenvironmental cues associated with multiple myeloma. We then describe how the individual canonical and non-canonical pathways transduce signals and contribute towards NF-κB -driven gene-expressions in healthy and malignant cells. Furthermore, we discuss signaling crosstalk between concomitantly triggered NF-κB pathways, and its plausible implication for anomalous NF-κB activation and NF-κB driven pro-survival gene-expressions in multiple myeloma. Finally, we propose that mechanistic understandin...Continue Reading

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Citations

Feb 10, 2019·International Journal of Molecular Sciences·Jonathan J MorganLisa J Crawford
Jun 4, 2020·Journal of Clinical Medicine·Karolina WoziwodzkaKatarzyna Krzanowska
May 28, 2019·Frontiers in Immunology·Budhaditya ChatterjeeSoumen Basak
Mar 29, 2019·JBMR Plus·Majdi MasarwiMichaela R Reagan
Apr 10, 2019·Expert Opinion on Investigational Drugs·Shirong LiKlaus Podar
Apr 3, 2020·International Journal of Molecular Medicine·Hailong TangGuangxun Gao
Jul 19, 2020·International Journal of Molecular Sciences·Sabah AkhtarShahab Uddin
Mar 11, 2020·Seminars in Cancer Biology·Vijay P KaleManoj K Pandey
Jun 30, 2021·NPJ Precision Oncology·Matthew A WallNitin S Baliga
May 28, 2019·Experimental Cell Research·Ming-Ming WangJian-Hua Tong

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
surface plasmon resonance
ChIP-seq
xenograft

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