The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction.

Molecular and Cellular Biology
M A Watson, J Milbrandt

Abstract

The NGFI-B cDNA was previously isolated by virtue of its induction by nerve growth factor (NGF) in PC12 cells. It encodes a 61-kilodalton protein that has two regions of extensive homology with members of the steroid/thyroid hormone receptor gene family. The rat NGFI-B gene is approximately 7.6 kilobases long and is interrupted by six introns. Although the exon-intron structure of the gene is similar to those of several other members of the steroid/thyroid hormone receptor gene family, there is a novel splice site within the DNA-binding domain which suggests that NGFI-B constitutes yet another evolutionary digression from a postulated common ancestral receptor gene. Primer extension and S1 nuclease protection assays were used to determine the transcription initiation site, which displayed the heterogeneity typical of genes that lack a TATA box. Sequence analysis of the 5' flanking region revealed several GC boxes but no identifiable TATA box. Four potential AP1 binding sites were identified at nucleotides -49, -78, -222, and -242. Neither the serum response element nor the CArG box element, two sequences found in other growth factor-inducible genes, was detected in this region of the growth factor-inducible NGFI-B gene. Neverth...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L Aloe, R Levi-Montalcini
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M Grunstein, D S Hogness
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F Tirone, E M Shooter
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S ChangelianJ Milbrandt
Dec 17, 1987·Nature·V GiguereR M Evans
Apr 28, 1988·Nature·N BrandA Dejean
Dec 18, 1986·Nature·C WeinbergerR M Evans
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Milbrandt
Jul 1, 1987·European Journal of Biochemistry·A Zahraoui, G Cuny
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D W SaffenJ M Baraban
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T G HazelL F Lau
Jan 1, 1988·The Journal of Cell Biology·D G LeonardE B Ziff
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P Masiakowski, E M Shooter
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C S HuckabyB W O'Malley
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Jan 1, 1982·Annual Review of Biochemistry·B A Yankner, E M Shooter
Jun 25, 1981·Journal of Molecular Biology·C C Baker, E B Ziff

❮ Previous
Next ❯

Citations

Feb 15, 2011·Brain Research Bulletin·Josh D Hawk, Ted Abel
Mar 27, 2007·General and Comparative Endocrinology·Meng Yao, Robert J Denver
Feb 1, 1992·Molecular and Cellular Neurosciences·J D WhiteC M Gall
Nov 3, 2004·Brain Research. Molecular Brain Research·Younsook ChoMargaret I Lomax
Feb 28, 2002·The European Journal of Neuroscience·P J FrenchT V Bliss
May 25, 2005·Biochemical and Biophysical Research Communications·Flavia Q PirihSotirios Tetradis
Apr 15, 2004·Molecular and Cellular Neurosciences·Juan Ji AnJa-Hyun Baik
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lars Peter Engeset AustdalRagnhild E Paulsen
Nov 24, 2016·Scientific Reports·Yanke ZhangBinglin Zhu
Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A V Krishnan, D Feldman
Jan 1, 1996·Journal of Molecular Neuroscience : MN·O Saucedo-Cardenas, O M Conneely
Jul 1, 1995·Journal of Neuroendocrinology·S Rivest, N Laflamme
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T Neumann-HaefelinK A Hossmann
May 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A M SomozaP Tarazona
Dec 1, 1994·Immunological Reviews·B A OsborneL M Schwartz
May 28, 1993·Annals of the New York Academy of Sciences·M VendrellJ I Morgan
Jan 1, 1995·Journal of Molecular Neuroscience : MN·R F PaulsenS Sterri
Jan 1, 1995·Journal of Molecular Neuroscience : MN·E Ciani, R E Paulsen
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Lindsey WestbrookMichael R Garrett
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Rivest
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Grazia Paola NicchiaMaria Svelto
Jan 5, 2000·The Journal of Biological Chemistry·F BlaeserT A Chatila
Oct 1, 2004·Molecular and Cellular Biology·Tiia Pönniö, Orla M Conneely
Jan 1, 1992·DNA Sequence : the Journal of DNA Sequencing and Mapping·M KeaveneyF Gannon
Aug 27, 2003·The Journal of Biological Chemistry·Daniel M FassRichard H Goodman
Oct 3, 2018·Molecular Medicine Reports·Lingjuan Wu, Liqun Chen
Sep 28, 2004·The Journal of Biological Chemistry·Chris M JacobsRagnhild E Paulsen
Jul 1, 1996·Journal of the American Geriatrics Society·S J Birge
May 2, 2003·Immunological Investigations·Yanxin LiuDexian Zheng
Aug 30, 2003·The Journal of Biological Chemistry·Xiaomin Mu, Chawnshang Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.