The NheA component of the non-hemolytic enterotoxin of Bacillus cereus is produced by Bacillus anthracis but is not required for virulence

Microbial Pathogenesis
Itai MendelsonArthur M Friedlander

Abstract

A non-hemolytic enterotoxin (NHE) is one of the two enterotoxins thought to cause diarrhea produced by Bacillus cereus. We identified genes in Bacillus anthracis homologous to the B. cereus nheAB genes encoding proteins of the NHE complex. The NheA component was detected immunologically in culture supernatants from B. anthracis but not from a NheA(-) mutant, suggesting that B. anthracis produces and secretes the NheA subunit of NHE. A NheA deletion mutant was not attenuated in the guinea pig suggesting that NheA is not absolutely required for virulence.

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Citations

Nov 3, 2010·Infection and Immunity·Amy JenkinsSusan Welkos
Nov 23, 2006·Journal of Bacteriology·Rebecca GiornoAdam Driks
May 23, 2007·BMC Microbiology·Annette FagerlundPer Einar Granum
May 25, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ben Raymond, Michael B Bonsall
Jan 30, 2010·Microbiology·Angelo ScorpioArthur M Friedlander
Aug 7, 2010·Microbiology·Inka SastallaStephen H Leppla
Apr 22, 2008·FEMS Microbiology Reviews·Lotte P Stenfors ArnesenPer Einar Granum
Nov 28, 2012·Microbial Pathogenesis·Jared D HeffronSusan L Welkos
Jun 4, 2014·Infection and Immunity·Tanya M JelacicArthur M Friedlander
Apr 20, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Leandro Pio de Sousa

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