The NHL-15 protocol for aggressive non-Hodgkin's lymphomas: a sequential dose-dense, dose-intense regimen of doxorubicin, vincristine and high-dose cyclophosphamide

Annals of Oncology : Official Journal of the European Society for Medical Oncology
C S PortlockJ R Bertino

Abstract

The NHL-15 protocol is a novel, dose-intense, dose-dense, sequential chemotherapy program developed to improve outcome in advanced, aggressive non-Hodgkin's lymphomas. The phase II NHL-15 protocol comprised: (i) induction [doxorubicin 60 mg/m(2) i.v. on weeks 1, 3, 5 and 7 plus vincristine 1.4 mg/m(2) i.v. (no cap) on weeks 1, 2, 3, 5 and 7]; and (ii) consolidation (cyclophosphamide 3000 mg/m(2) i.v. on weeks 9, 11 and 13 plus granulocyte colony-stimulating factor 5 microg/kg subcutaneous on days 3-10 following each cyclophosphamide dose). Patients with aggressive non-Hodgkin's lymphomas (working formulation: intermediate grade or immunoblastic), bulky stage I and stages II-IV, were eligible. There are 165 eligible patients with a 6.9-year median follow-up (range 0.5-141 months) and a median age of 48 years. For the entire group, 72.1% achieved complete remission, and at 5 years disease-free survival was 57.8% and overall survival (OS) was 62.2%. Ideal dose delivery was >90%. Acute and late toxicities of treatment were manageable and acceptable. Toxic death on treatment was 2.4%. When the diffuse large cell lymphoma histologies were grouped according to the International Prognostic Index (IPI), complete remission and OS in the ...Continue Reading

References

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Citations

Jul 16, 2011·Cancer Chemotherapy and Pharmacology·John L ReaganAnthony E Mega
Apr 8, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jeffrey A JonesLinda S Elting
May 10, 2007·Leukemia & Lymphoma·Bruce A PetersonUNKNOWN Cancer and Leukemia Group B 9351
Nov 26, 2015·Human Molecular Genetics·Mohammad A EsmaeiliMahmoud Kiaei
Feb 19, 2009·International Journal of Surgical Pathology·Mohamed E SalamaSherrie L Perkins
Aug 15, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Eri MatsukiJulie Teruya-Feldstein

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