The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results

American Journal of Epidemiology
M FeinleibJ O Wagner


Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, glucose intolerance, uric acid, plasma triglyceride, and relative weight but little or no significant genetic variability in low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total plasma cholesterol or hematocrit was demonstrable. These findings suggest that familial aggregation results from genetic influence on blood pressure, glucose intolerance, uric acid, triglyceride and, possibly, obesity, while largely shared environmental factors contribute to familial similarities in HDL, LDL, total cholesterol and hematocrit.


Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·R R WilliamsH Kuida
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L PérusseC Bouchard
Jan 1, 1988·Acta geneticae medicae et gemellologiae·R FabsitzJ Christian
Jan 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J G Mongeau
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T KuusiM Koskenvuo
Jan 1, 1987·Genetic Epidemiology·S KalousdianR Rosenman
Jul 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U Goldbourt, H N Neufeld
May 1, 1985·Psychophysiology·D I Boomsma, W F Gabrielli
Sep 1, 1980·Sozial- Und Präventivmedizin·F DornerA Spahr
Sep 1, 1982·Hypertension·R J Havlik, M Feinleib
Aug 1, 1980·Postgraduate Medical Journal·N E Miller
May 1, 1995·Clinical Genetics·K L EdwardsG P Jarvik
Dec 1, 1995·Hypertension·Robert H FagardRobert Vlietinck
Jan 2, 1995·American Journal of Medical Genetics·J B CroftM Swift
Nov 1, 1993·Hypertension·K TambsP G Lund-Larsen
Nov 1, 1996·Hypertension·L P SvetkeyA F Wilson
Apr 1, 1997·The British Journal of Nutrition·J M De Castro
Jan 1, 1997·Genetic Epidemiology·K L EdwardsM A Austin
Apr 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S JahanfarD E Wilcken
Oct 31, 1998·Journal of Hypertension·P HametJ Tremblay
Mar 6, 1999·Stroke; a Journal of Cerebral Circulation·C DeCarliD Carmelli
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·H SniederD I Boomsma
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·B UçarK Ozdamar
Jun 7, 2002·Endocrine Reviews·Munro PeacockTatiana Foroud
Jun 21, 2003·Journal of Hypertension·Robert H FagardRobert Vlietinck
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Giang H NguyenCassandra L Smith
Jul 2, 2004·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Christine A WyndRichard A Zeller
Mar 5, 2005·Stroke; a Journal of Cerebral Circulation·Enrico Flossmann, Peter M Rothwell
Feb 11, 2005·Nature Reviews. Genetics·Christopher G BellPhilippe Froguel
Jan 18, 2006·American Journal of Medical Genetics. Part a·Terry ReedShannon A Rinehart
May 23, 2012·International Journal of Clinical Practice·A Banerjee
Apr 12, 2013·Journal of Immigrant and Minority Health·A M N RenzahoG C Marks
Mar 9, 2013·Genes & Nutrition·William S GarverRobert A Orlando
Feb 19, 2015·International Journal of Hypertension·Mariel Van WoudenbergZdenka Pausova
Nov 2, 2015·Current Cardiology Reports·David S Geller
Feb 6, 2017·Journal of the American Heart Association·Justin R RyderJulia Steinberger

Related Concepts

Coronary Heart Disease Risk
Low Density Lipoprotein Cholesterol Measurement
HLA DZ antigen
Diastolic Blood Pressure
Total cholesterol
Serum Total Cholesterol Measurement

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.