The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results

American Journal of Epidemiology
M FeinleibJ O Wagner

Abstract

Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, glucose intolerance, uric acid, plasma triglyceride, and relative weight but little or no significant genetic variability in low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total plasma cholesterol or hematocrit was demonstrable. These findings suggest that familial aggregation results from genetic influence on blood pressure, glucose intolerance, uric acid, triglyceride and, possibly, obesity, while largely shared environmental factors contribute to familial similarities in HDL, LDL, total cholesterol and hematocrit.

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Related Concepts

Coronary Heart Disease Risk
Study
Epicholesterol
Low Density Lipoprotein Cholesterol Measurement
HLA DZ antigen
Urate
Diastolic Blood Pressure
Aggregation
Total cholesterol
Serum Total Cholesterol Measurement

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