The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease

Archives of Neurology
K L LeendersR S Frackowiak

Abstract

A group of healthy control subjects and patients with Parkinson's disease were investigated using positron emission tomography and two tracers as indicators of different specific properties of the presynaptic dopaminergic system in caudate nucleus and putamen. The first tracer, 6-L-(18F)-fluorodopa, was used as an analog of levodopa to assess its regional brain uptake, conversion into, and retention as dopamine and further metabolites. The second tracer, (11C)-nomifensine was employed as an indicator of striatal monaminergic reuptake sites that are principally dopaminergic. We have used this tracer to assess dopaminergic nerve terminal density. In patients with Parkinson's disease, striatal uptake of both tracers was decreased, putamen being significantly more affected than caudate. Side-to-side differences of uptake in putamen, but not caudate, correlated with corresponding left-right differences of scored clinical motor performance. Both 6-L(18F)-fluorodopa and (11C)-nomifensine tracer uptake in putamen was decreased on average to 40% of normal values, suggesting that a substantial part of the cellular elements of the dopaminergic nigrostriatal system is still intact in living parkinsonian patients. This is in contrast to the...Continue Reading

Citations

Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·R E YeeJ R Barrio
Jun 11, 1992·The New England Journal of Medicine·S Gilman
Jul 18, 2014·PET Clinics·Sotirios ChondrogiannisDomenico Rubello
Feb 1, 1995·Molecular and Chemical Neuropathology·P AngladeE C Hirsch
May 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·M RodriguezJ A Obeso
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS Wang
Nov 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·J O RinneO Solin
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J C M ZijlmansA J L Lees
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David J Brooks
Sep 1, 2006·Neuropsychiatric Disease and Treatment·Patrick McNamaraAriel Brown
Jan 9, 2010·Journal of Neurology·I NestrasilPaul J Tuite
Jan 12, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason M WilliamsMalcolm J Avison
Apr 13, 2010·Neuropsychology Review·Alice Cronin-Golomb
Feb 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicolaas I Bohnen, Kirk A Frey
Dec 18, 2012·Zeitschrift für Gerontologie und Geriatrie·L C BollheimerR Büttner
Nov 25, 2000·Psychiatry Research·A M ElkashefR J Wyatt
May 8, 2010·Indian Journal of Cancer·P CaroliS Fanti
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·S M Aquilonius
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A B Newberg, A Alavi
Jan 17, 2013·Journal of Clinical and Experimental Neuropsychology·Paul S FosterKenneth M Heilman
Oct 10, 2002·Biological Psychiatry·Aki LaaksoJarmo Hietala
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J A StanfordG A Gerhardt
Feb 3, 2012·Journal of Neurology·Marios Politis, Paola Piccini
Oct 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S A EshuisP L Jager
Nov 28, 2008·European Journal of Nuclear Medicine and Molecular Imaging·S A EshuisK L Leenders
Mar 1, 1993·Journal of the Neurological Sciences·D J Brooks
Oct 6, 2012·Cancer Biotherapy & Radiopharmaceuticals·Egesta LopciStefano Fanti
Oct 11, 2005·Journal of the International Neuropsychological Society : JINS·J Vincent FiloteoDavid D Song
Nov 6, 2003·Neuroscience and Biobehavioral Reviews·C A Shaw, J M B Wilson
Dec 20, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Anna L Bartels, Klaus L Leenders
May 18, 2000·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·T ZallaJ Grafman
Jul 16, 2015·Human Gene Therapy·Andrii DomanskyiMikko Airavaara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R TorstensonB Långström
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
D B StoutJ R Barrio
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
J R BarrioM E Phelps
Advances in Health Sciences Education : Theory and Practice
Eta S Berner
© 2021 Meta ULC. All rights reserved