The NIMH Research Domain Criteria Initiative: Background, Issues, and Pragmatics

Psychophysiology
Michael J Kozak, Bruce N Cuthbert

Abstract

This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highlighted: subjectivism and heterophenomenology, desynchrony and theoretical neutrality among units of analysis, theoretical reductionism, endophenotypes, biomarkers, neural circuits, construct "grain size," and analytic challenges. The importance of linking RDoC constructs to psychiatric clinical problems is discussed. Some pragmatics of incorporating RDoC concepts into applications for NIMH research funding are considered, including sampling design.

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Citations

Feb 16, 2016·Psychophysiology·Christopher J Patrick, Greg Hajcak
Feb 16, 2016·Psychophysiology·Gregory L Hanna, William J Gehring
Feb 16, 2016·Psychophysiology·Gregory A MillerCindy M Yee
Feb 16, 2016·Psychophysiology·Judith M Ford
Feb 16, 2016·Psychophysiology·Robert F Krueger, Colin G DeYoung
Feb 16, 2016·Psychophysiology·Stephan Heckers
Feb 16, 2016·Psychophysiology·Dario Maestripieri, Scott O Lilienfeld
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