The nitric oxide donor nitroprusside intraperitoneally affects peritoneal permeability in CAPD

Kidney International
C E DoumaR T Krediet

Abstract

Nitroprusside is a nitric oxide (NO) donor. To investigate effects of nitroprusside i.p. on peritoneal permeability and perfusion, standard peritoneal permeability analyses were performed. Ten stable CAPD patients were studied twice within one week with glucose based dialysate (1.36% Dianeal) with and without addition of nitroprusside 4.5 mg/liter. Mass transfer area coefficients (MTAC) of CO2 were calculated to estimate peritoneal blood flow. Nitrate, a stable metabolite of NO, and cGMP, a second messenger of NO synthesis, were measured in plasma and dialysate. The MTACs of low molecular weight solutes were greater with nitroprusside (NP) compared to the control dwell (C): creatinine median 14.1 (NP) versus 9.9 ml/min (C), urea 21.7 (NP) versus 18.5 ml/min (C) and urate 10.5 (NP) versus 8.6 ml/min (C) (P < 0.05 for all). This points to an increased effective peritoneal surface area with nitroprusside. Furthermore, the restriction coefficient for the low molecular weight solutes decreased from 1.28 (C) to 1.23 (NP) (P = 0.02), suggesting some effect also on the size selectivity to these solutes. The effect of nitroprusside on the clearances of serum proteins was more pronounced. The increase with nitroprusside was 34% for beta ...Continue Reading

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Citations

Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Teresa Yuk-Hwa WongPhilip Kam-Tao Li
Dec 16, 1998·Kidney International·R T KredietD G Struijk
Aug 5, 1999·Kidney International·J WaniewskiB Lindholm
Feb 19, 2002·Kidney International·Toshio MiyataCharles van Ypersele de Strihou
Aug 5, 2005·Journal of the American Society of Nephrology : JASN·El Rasheid ZakariaR Neal Garrison
May 15, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Deirisa Lopes Barreto, Raymond T Krediet
Nov 25, 2003·Kidney International·Stanislao MorgeraHans-Hellmut Neumayer
Dec 17, 2008·European Journal of Pharmacology·Stefania MondelloSalvatore Cuzzocrea
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·C E DoumaR T Krediet
Aug 12, 1999·The Journal of Laboratory and Clinical Medicine·M M ZweersR T Krediet
May 3, 2006·The Journal of Surgical Research·Robert NachtsheimThomas R Howdieshell
Nov 10, 2000·Advances in Renal Replacement Therapy·R T Krediet
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Feb 27, 2004·The International Journal of Artificial Organs·A DavenportZ Varghese
Nov 17, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Jacek WaniewskiBengt Lindholm
Jan 21, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Raymond T KredietAndrew Davenport
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Sophie CombetOlivier Devuyst
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·S CombetO Devuyst

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