The nitric oxide-iron interplay in mammalian cells: transport and storage of dinitrosyl iron complexes

Biochimica Et Biophysica Acta
Des R Richardson, Hiu Chuen Lok

Abstract

Nitrogen monoxide (NO) is a vital effector and messenger molecule that plays roles in a variety of biological processes. Many of the functions of NO are mediated by its high affinity for iron (Fe) in the active centres of proteins. Indeed, NO possesses a rich coordination chemistry with this metal and the formation of dinitrosyl-dithiolato-Fe complexes (DNICs) is well known to occur intracellularly. In mammals, NO produced by activated macrophages acts as a cytotoxic effector against tumour cells by binding and releasing cancer cell Fe that is vital for proliferation. Glucose metabolism and the subsequent generation of glutathione (GSH) are critical for NO-mediated Fe efflux and this process occurs by active transport. Our previous studies showed that GSH is required for Fe mobilisation from tumour cells and we hypothesized it was effluxed with Fe as a dinitrosyl-diglutathionyl-Fe complex (DNDGIC). It is well known that Fe and GSH release from cells induces apoptosis, a crucial property for a cytotoxic effector like NO. Furthermore, NO-mediated Fe release is mediated from cells expressing the GSH transporter, multi-drug resistance protein 1 (MRP1). Interestingly, the glutathione-S-transferase (GST) enzymes act to bind DNDGICs w...Continue Reading

References

Dec 18, 1992·Science·J S StamlerJ Loscalzo
Jun 29, 1992·Biochimica Et Biophysica Acta·A F VaninD Sh Burbaev
Aug 30, 1991·Biochemical and Biophysical Research Communications·M LepoivreM Fontecave
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J R Lancaster, J B Hibbs
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Aug 13, 1968·Biochimica Et Biophysica Acta·J C WoolumB Commoner
Sep 17, 1984·Biochemical and Biophysical Research Communications·J B HibbsZ Vavrin
Dec 8, 1995·The Journal of Biological Chemistry·M BoeseA Mülsch
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·O G KhatsenkoJ R Vane
Sep 1, 1994·The Journal of Experimental Medicine·G WeissM W Hentze
Sep 23, 1994·Cell·C Nathan, Q W Xie
Mar 17, 1995·The Journal of Biological Chemistry·Y M KimJ R Lancaster
Jul 1, 1996·Molecular and Cellular Biology·K PantopoulosM W Hentze
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M W Hentze, L C Kühn
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Ding, B Demple
Aug 1, 1997·Nature Genetics·J V Gray, K J Johnson
Mar 14, 1997·Biochimica Et Biophysica Acta·D R Richardson, P Ponka
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D FlemingN C Andrews
Apr 17, 1998·Cancer Metastasis Reviews·D A Geller, T R Billiar
Dec 16, 1998·Nitric Oxide : Biology and Chemistry·A F VaninM V Genkin
Nov 24, 1999·The Journal of Laboratory and Clinical Medicine·D R Richardson
Dec 23, 1999·The New England Journal of Medicine·N C Andrews

❮ Previous
Next ❯

Citations

Dec 14, 2011·Cell Biochemistry and Biophysics·Enika Nagababu, Joseph M Rifkind
Oct 25, 2012·International Journal of Hepatology·Julie PajaudCaroline Aninat
Jul 31, 2013·PloS One·Surasri N SahuHediye Nese Cinar
Feb 5, 2014·European Journal of Pharmacology·Evgeniya N BurgovaAnatoly F Vanin
Sep 7, 2011·Plant Science : an International Journal of Experimental Plant Biology·Leonor RamirezLorenzo Lamattina
Apr 16, 2009·Nitric Oxide : Biology and Chemistry·Anatoly F Vanin
Sep 13, 2008·Biochimica Et Biophysica Acta·Günter Weiss
Sep 4, 2015·The Plant Journal : for Cell and Molecular Biology·Varanavasiappan ShanmugamKuo-Chen Yeh
Nov 10, 2011·The Plant Journal : for Cell and Molecular Biology·Varanavasiappan ShanmugamKuo-Chen Yeh
Sep 28, 2010·Journal of Cellular Biochemistry·Su Hee HanSung-Jin Kim
May 18, 2013·Biotechnology Advances·Behrooz DarbaniSøren Borg
May 31, 2011·Free Radical Biology & Medicine·Tim Van AsschePaul Cos
Apr 22, 2010·Free Radical Biology & Medicine·Juanjuan YangHuangen Ding
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Fredy R S GutierrezJoão S Silva
Jun 17, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Hanna LewandowskaMarcin Kruszewski
Oct 19, 2011·Toxicologic Pathology·Ivan RousseauSusana Puntarulo
Jun 22, 2017·Nanomedicine·Hafiz Shoaib SarwarGul Shahnaz
Aug 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nataliya SaninaAlexei Terent'ev
Jul 16, 2019·Chemical Communications : Chem Comm·Daniela R TruzziPeter C Ford
Mar 4, 2020·International Journal of Molecular Sciences·Ricardo U Macías-RodríguezFrancisco Javier Cubero
Dec 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alessio BocediGiorgio Ricci
Dec 7, 2019·Cellular and Molecular Life Sciences : CMLS·Marc LlavaneraMarc Yeste
Apr 28, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Kelsey M SkodjeEunsuk Kim
May 16, 2013·Chemical Communications : Chem Comm·Jessica FitzpatrickEunsuk Kim
Oct 23, 2008·Journal of the American Chemical Society·Todd C HarropStephen J Lippard
May 21, 2021·Inorganic Chemistry·Daniela R TruzziPeter C Ford
Sep 20, 2019·Inorganic Chemistry·Daniela R TruzziPeter C Ford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.