PMID: 9161609May 1, 1997Paper

The nitric oxide synthase inhibitor L-NAME (N omega-nitro-L-arginine methyl ester) does not produce discriminative stimulus effects similar to ethanol

Alcoholism, Clinical and Experimental Research
K L GreenK A Grant

Abstract

N-methyl-D-aspartate (NMDA) antagonists substitute for the discriminative stimulus effects of ethanol, indicating that a component of ethanol's behavioral activity is produced via blockade of NMDA receptor/channel function. Recently, it has been reported that ethanol inhibits NMDA-stimulated nitric oxide synthase (NOS) activity in cortical neurons, thereby decreasing the formation of nitric oxide (NO) in the brain. These findings suggest that some of the behavioral effects of ethanol may be mediated by inactivation of NOS. The present study examined the role of NO formation in mediating the discriminative stimulus effects of ethanol. To address this hypothesis, an NOS inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME) and an NMDA competitive antagonist, (D)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (CPPene), were administered to two groups of rats trained to discriminate 1.5 g/kg of ethanol (n = 6) or 2.0 g/kg (n = 7) of ethanol from water. After training, dose ranges of CPPene (3 to 17 mg/kg, ip) and L-NAME (100 to 780 mg/kg, ip) were tested for ethanol-like effects. L-NAME was also tested under a range of pretreatment times (20, 60, 90, and 120 min). An additional group of rats trained to discriminate 2.0...Continue Reading

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Citations

Jun 24, 2003·European Journal of Pharmacology·James B Smith, Alison A Ogonowski
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·M NaassilaM Daoust
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·E KorosP Bienkowski
May 29, 2002·Archives of Medical Research·Paavo Pokk, Marika Väli
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paavo Pokk, Marika Väli
Jul 17, 1998·Alcohol·M L Adams, T J Cicero
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant

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