PMID: 8938819Oct 1, 1996Paper

The nitric oxide synthesis inhibitor L-NAME facilitates associative learning

Progress in Neuro-psychopharmacology & Biological Psychiatry
W Du, J A Harvey

Abstract

1. Nitric oxide has been suggested to play an important role in synaptic plasticity and in learning. 2. The authors examined the effects of NW-nitro-L-arginine methyl ester, a competitive and enantiomeric specific inhibitor of nitric oxide synthase, on classical conditioning of the rabbit's nictitating membrane response. 3. It was found that L-NAME significantly enhanced the acquisition of conditioned responses. 4. The enhanced conditioned responses were not due to a sensitization of the conditioned and unconditioned reflexes or to changes in baseline levels of responding. 5. The dose and route of administration of L-NAME employed in this study had no effect on blood pressure. 6. These results suggest that nitric oxide normally functions as a tonic inhibitory modulator of associative learning and that procedures aimed at decreasing its production may provide a novel approach for improving learning.

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Citations

May 26, 1999·Pharmacology, Biochemistry, and Behavior·J O CampbellL P Spear
Feb 19, 2002·Brain Research Bulletin·Elisabeth Wazlawik, Gina S Morato
Aug 23, 2012·Behavioural Brain Research·Çiğdem Gökçek-SaraçEwa Jakubowska-Doğru
Jun 16, 2011·Behavioural Brain Research·Georgia Georgiadou, Nikolaos Pitsikas
Jun 17, 2014·Behavioural Brain Research·Nikolaos Pitsikas
Mar 20, 1999·Neurobiology of Learning and Memory·B Samama, N Boehm
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jong-Seon ByunWanjoo Chun

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