The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats

European Journal of Pharmacology
Mónica GarcíaL San Román

Abstract

We investigated the involvement of the nitric oxide pathway in the inhibitory mechanisms of 5-hydroxytryptamine (5-HT) in the pressor responses induced by stimulation of sympathetic vasopressor outflow in diabetic pithed rats. Diabetes was induced in male Wistar rats by a single s.c. injection of alloxan. Four weeks later, the animals were anaesthetized, pretreated with atropine, and pithed. Electrical stimulation of the sympathetic outflow from the spinal cord (0.1, 0.5, 1 and 5 Hz) resulted in frequency-dependent increases in blood pressure. The inhibition of electrically induced pressor responses by 5-HT (10 microg/kg/min) in diabetic pithed rats could not be elicited after i.v. treatment with 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) (10 microg/kg), a guanylyl cyclase inhibitor, or N-omega-L-Arginine methyl ester hydrochloride (L-NAME) (10 mg/kg), a nitric oxide synthase (NOS) inhibitor. The inhibitory effect produced by infusion of the selective 5-HT(1A) receptor agonist 8-hydroxydipropylaminotretalin hydrobromide (8-OH-DPAT) (20 microg/kg/min) was abolished in the presence of ODQ (10 microg/kg), or L-NAME (10 mg/kg) in diabetic pithed rats. The administration of L-Arginine (100 mg/kg) 30 min after L-NAME reproduce...Continue Reading

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Citations

Jun 2, 2012·Intensive Care Medicine·Nils NeyeWolfgang M Kuebler
Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Feb 26, 2011·Neuroscience and Biobehavioral Reviews·Canteros Maria Griselda
Oct 27, 2007·Journal of Ethnopharmacology·Elena Matteucci, Ottavio Giampietro
Mar 17, 2016·International Journal of Psychiatry in Clinical Practice·Murat GulsunYasemin Kurt
Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
May 25, 2015·Vascular Pharmacology·José-Ángel García-PedrazaAsunción Morán
Jun 19, 2013·European Journal of Pharmacology·José Ángel García-PedrazaAsunción Morán
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·Mónica GarcíaLuis San Román
Sep 24, 2016·Scientific Reports·José-Ángel García-PedrazaAsunción Morán
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dong-Feng YeihYung-Zu Tseng
Jul 24, 2021·Journal of Pharmacological Sciences·José Ángel García-PedrazaMónica García-Domingo

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