The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies.

Nature Immunology
Tobias BaldKevin C Barry

Abstract

Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or transformed cells. Additionally, via cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer. Current strategies in preclinical and clinical development include adoptive transfer therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME to enhance antitumor NK cell function. In this Review, we introduce the NK cell-cancer cycle to highlight recent advances in NK cell biology and to discuss the progress and problems of NK cell-based cancer immunotherapies.

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Methods Mentioned

BETA
xenograft
transfect

Clinical Trials Mentioned

NCT02983045
NCT03635983
NCT04209114
NCT03729245
NCT02989844
NCT03586869
NCT03387098
NCT03329248
NCT03228667
NCT03136406

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