The NK(1) receptor antagonist WIN51708 reduces sensitization after chronic cocaine

European Journal of Pharmacology
Colin DavidsonEverett H Ellinwood

Abstract

We tested the tachykinin NK(1) receptor antagonist WIN51708 (17betahydroxy17alphaethynyl5alphaandrostanol[3,2b]pyrimido[1,2-a]benzimidazole) in a behavioral sensitization model. Rats were given 7 days of cocaine then 7 days of withdrawal to induce sensitization. Thereafter, another 7 days of cocaine with WIN51708 (2 mg/kg i.p.) given 3.5 h after each cocaine injection was given. WIN51708 reversed sensitization but had no effect on controls. NK(1) receptor antagonists may have use in stimulant abuse and schizophrenia treatment.

Citations

Aug 30, 2008·Reviews in the Neurosciences·Maria A de Souza SilvaChristian P Müller
Jun 6, 2014·ACS Medicinal Chemistry Letters·Stephen HanessianGuillaume De Nanteuil

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