The NLRP1-IL18 Connection: A Stab in the Back of Obesity-Induced Inflammation

Cell Metabolism
Mihai G Netea, Leo A B Joosten

Abstract

IL-18 has been reported to counteract obesity and metabolic syndrome, though the underlying mechanisms remain unclear. In this issue, Masters and colleagues describe how NLRP1 inflammasome induces IL-18 production in fat, solving not only an important biological mechanism, but also opening the door for therapeutic approaches (Murphy et al., 2016).

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Citations

Aug 4, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nikolett LénártÁdám Dénes
Jul 30, 2019·Journal of Cardiovascular Pharmacology·Marina SokolovaPal Aukrust
Sep 26, 2019·Cellular & Molecular Immunology·Xabier UnamunoVictoria Catalán
Oct 5, 2019·Journal of Cardiovascular Pharmacology·Marina SokolovaPål Aukrust
Oct 16, 2018·Frontiers in Immunology·Jingyun Luan, Dianwen Ju

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