The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats

Behavioural Pharmacology
E ZakharovaA Bespalov

Abstract

Several drugs, such as N-methyl-D-aspartate (NMDA) receptor channel blockers (memantine), naltrexone (but not naloxone) and acamprosate, have previously been reported to attenuate the expression of the alcohol deprivation effect, a phenomenon seen as an increase in post-deprivation alcohol consumption. The present study aimed to evaluate the effects of these drugs on the development and expression of the saccharin deprivation effect in adult male Wistar rats. Memantine (13 mg/kg per day) and naltrexone (5 mg/kg, twice daily), but not naloxone (24 mg/kg per day) or acamprosate (200 mg/kg, twice daily), prevented the increase in the consumption of saccharin after a 1-week deprivation from free-choice, unlimited access to saccharin (0.1%, w/v). Taken together with the results of previous studies, these results suggest that naltrexone and memantine attenuate the expression of both the alcohol and saccharin deprivation effects.

References

Jun 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N K Mello, S S Negus
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Zieglgänsberger
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Hundt
Oct 31, 1996·European Journal of Pharmacology·S M HölterR Spanagel
Jan 1, 1997·Psychopharmacology·A Herz
May 20, 1997·European Journal of Pharmacology·A Bespalov, E Zvartau
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·R Spanagel, S M Hölter
Jul 22, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A B Kampov-PolevoyD S Janowsky
Apr 26, 2000·Behavioural Pharmacology·T A KostenP Jatlow
Aug 16, 2000·Journal of Neural Transmission·R Spanagel, S M Hölter
Aug 1, 1992·Behavioural Pharmacology·A. JacksonF.C. Colpaert
Oct 9, 2002·Behavioral Neuroscience·Olga N NeznanovaAnton Y Bespalov

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Citations

Jul 29, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Valentina VengelieneAnton Bespalov
Jan 12, 2005·Physiology & Behavior·Jeffrey W GrimmDan P Osincup
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein

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