The NMDA receptor participates in respiration-related mitral cell synchrony

Experimental Brain Research
B D PhilpotP C Brunjes

Abstract

The N-methyl-D-aspartate (NMDA)-type glutamate receptor participates in the excitation of olfactory bulb mitral cells and is important in granule-cell-mediated feedback-inhibition. In the present study, extracellular unit recordings were made in vivo to demonstrate that the firing rates of mitral cells are not affected by peripheral administration of the non-competitive NMDA receptor antagonist MK-801. However, while over 50% of odor-driven mitral cell activity is normally correlated with the respiratory cycle, only about 10% of mitral cell activity is correlated with the respiratory cycle 30 min after MK-801 administration. Thus, the NMDA receptor is a participant in normal respiration-related mitral cell activity and may have an important role in the formation of bulb oscillations that encode olfactory information. Furthermore, the NMDA receptor is in a position to mediate activity-dependent changes in the bulb that rely on synchronous activity.

Citations

Oct 27, 2004·Physiology & Behavior·Bettina M Pause
Apr 2, 2003·Brain Research. Brain Research Reviews·Michael Leon, Brett A Johnson
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J KihmG K Owens
Jun 25, 2003·Psychophysiology·Bettina M PauseRoman Ferstl
May 20, 2008·NeuroImage·Joachim H LaudienBettina M Pause
May 3, 2001·Journal of Neurobiology·B K Fiske, P C Brunjes
Nov 28, 2002·The Journal of Comparative Neurology·Jennifer M MirichPeter C Brunjes
Dec 25, 2004·Physiological Reviews·Pierre-Marie LledoJean-Didier Vincent
Dec 13, 2005·Chemical Senses·Nathalie BuonvisoPhilippe Litaudon
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan M BarmanGerard L Gebber

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